This pioneering study evaluates the digital divide and advances in virtual education (VE) and e-learning research in the Global South Countries (GSCs). Using metadata from bibliographic and World Bank data on research and development (R&D), we conduct quantitative bibliometric performance analyses and evaluate the connection between R&D expenditures on VE/e-learning research advances in GSCs. The results show that ‘East Asia and the Pacific’ (EAP) spent significantly more on (R&D) and achieved the highest scientific literature publication (SLP), with significant impacts. Other GSCs’ R&D expenditure was flat until 2020 (during COVID-19), when R&D funding increased, achieving a corresponding 42% rise in SLPs. About 67% of ‘Arab States’ (AS) SLPs and 60% of citation impact came from SLPs produced from global north and other GSCs regions, indicating high dependence. Also, 51% of high-impact SLPs were ‘Multiple Country Publications’, mainly from non-GSC institutions, indicating high collaboration impact. The EAP, AS, and ‘South Asia’ (SA) regions experienced lower disparity. In contrast, the less developed countries (LDCs), including ‘Sub-Sahara Africa’, ‘Latin America and the Caribbean’, and ‘Europe (Eastern) and Central Asia’, showed few dominant countries with high SLPs and higher digital divides. We advocate for increased educational research funding to enhance innovative R&D in GSCs, especially in LDCs.