The availability of well-paid jobs in the regions plays a crucial role in today's regional development, as it provides employment opportunities, prosperity and stimulates the population to stay in the regions. In view of the ever-shrinking population in rural areas, it is essential to create instruments to support the creation of new jobs that are directly aimed at attracting human resources to the regions. The aim of the study is to conduct a research on job opportunities in the regions of Latvia. It evaluates job opportunities in the regions of Latvia. The study analyses the dynamics of available jobs in the regions of Latvia, wages, municipal support tools, influencing factors and analysis of best practices. Various economic instruments are being considered that could contribute to the creation of new well-paid jobs in the regions. The study included feasibility study interviews, statistical data analysis, focus groups and expert survey. The result of the study is an assessment of the current situation regarding job opportunities in the regions of Latvia. The study finds solutions for creating new jobs and attracting labour force to the regions ability to create well-paid jobs. Business support is recommended for companies with the potential to transform from small to medium-sized enterprises, resulting in a greater positive impact on the number and quality of jobs. More substantial support should be provided to companies whose growth is based on export or import substitution, as well as to companies investing in machine-based innovations.