A significant portion of the Indian population lives in villages, some of which are located in grid-disconnected remote areas. The supply of electricity to these villages is not feasible or cost-effective, but an autonomous integrated hybrid renewable energy system (IHRES) could be a viable alternative. Hence, this study proposed using available renewable energy resources in the study area to provide electricity and freshwater access for five un-electrified grid-disconnected villages in the Odisha state of India. This study concentrated on three different kinds of battery technologies such as lithium-ion (Li-Ion), nickel-iron (Ni-Fe), and lead-acid (LA) along with a diesel generator to maintain an uninterrupted power supply. Six different configurations with two dispatch strategies such as load following (LF) and cycle charging (CC) were modelled using nine metaheuristic algorithms to achieve an optimally configured IHRES in the MATLAB© environment. Initially, these six configurations with LF and CC strategies were evaluated with the load demands of a low-efficiency appliance usage-based scenario, i.e., without demand-side management (DSM). Later, the optimal configuration obtained from the low-efficiency appliance usage-based scenario was further evaluated with LF and CC strategies using the load demands of medium and high-efficiency appliance usage-based scenarios, i.e., with DSM. The results showed that the Ni-Fe battery-based IHRES with LF strategy using the high-efficiency appliance usage-based scenario had a lower life cycle cost of USD 522,945 as compared to other battery-based IHRESs with LF and CC strategies, as well as other efficiency-based scenarios. As compared to the other algorithms used in the study, the suggested Salp Swarm Algorithm demonstrated its fast convergence and robustness effectiveness in determining the global best optimum values. Finally, the sensitivity analysis was performed for the proposed configuration using variable input parameters such as biomass collection rate, interest rate, and diesel prices. The interest rate fluctuations were found to have a substantial impact on the system’s performance.