2024
DOI: 10.1039/d4sc01992j
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Employing unnatural promiscuity of sortase to construct peptide macrocycle libraries for ligand discovery

Yan-Ni Zhang,
Xiao-Cui Wan,
Yang Tang
et al.

Abstract: We report a sortase-based macrocyclization strategy in which low-reactive electrophiles are introduced into the SrtA recognition sequence (LPXTG) to enable the construction of phage-displayed peptide macrocycle libraries for ligand discovery.

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