Empowered with Movement to Prevent Obesity &amp; Weight Regain (EMPOWER): Design and methods

Objective: The purpose of this study was to determine whether baseline measures of hedonic hunger-the Power of Food Scale-and selfcontrol for food consumption-the Weight Efficacy Lifestyle Questionnaire-were associated with network topology within two sets of brain regions (regions of interest [ROIs] 1 and 2) in a group of older adults with obesity. These previously identified brain regions were shown in a different cohort of older adults to be critical for discriminating weight loss success and failure. Methods: Baseline functional magnetic resonance imaging data (resting state and food cue task) were collected in a novel cohort of 67 older adults with obesity (65-85 years, BMI = 35-42 kg/m 2) participating in an 18-month randomized clinical trial on weight regain. Results: The Power of Food Scale was most related to ROI 1, which includes the visual cortex and sensorimotor processing areas during only the food cue state. During both the food cue and resting conditions, the Weight Efficacy Lifestyle Questionnaire was associated with ROI 2, which includes areas of the attention network and limbic circuitry. Conclusions: Our findings show critical, distinct links between brain network topology with self-reported measures that capture hedonic hunger and the confidence that older adults have in resisting the consumption of food because of both intrapersonal and social/environmental cues.

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Overview Of the Empower Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Functional Brain Networks: Unique Patterns with Hedonic Appetite and Confidence to Resist Eating in Older Adults with Obesity

Burdette

Laurienti

Miron

et al. 2020

Intervening on exercise and daylong movement for weight loss maintenance in older adults: A randomized, clinical trial

Fanning

Rejeski

Leng

et al. 2021

Self Cite

Objective This study aimed to determine the impact of dietary weight loss (WL) plus aerobic exercise (EX) and a “move more, more often” approach to activity promotion (SitLess; SL) on WL and maintenance. Methods Low‐active older adults (age 65‐86 years) with obesity were randomized to WL+EX, WL+SL, or WL+EX+SL. Participants received a social‐cognitive group‐mediated behavioral WL program for 6 months, followed by a 12‐month maintenance period. EX participants received guided walking exercise with the goal of walking 150 min/wk. SL attempted to achieve a step goal by moving frequently during the day. The primary outcome was body weight at 18 months, with secondary outcomes including weight regain from 6 to 18 months and objectively assessed physical activity and sedentary behavior at each time point. Results All groups demonstrated significant WL over 6 months (p < 0.001), with no group differences. Groups that received SL improved total activity time (p ≤ 0.05), and those who received EX improved moderate‐to‐vigorous activity time (p = 0.003). Over the 12‐month follow‐up period, those who received WL+EX demonstrated greater weight regain (5.2 kg; 95% CI: 3.5‐6.9) relative to WL+SL (2.4 kg; 95% CI: 0.8‐4.0). Conclusions Pairing dietary WL with a recommendation to accumulate physical activity contributed to similar WL and less weight regain compared with traditional aerobic exercise.

Longitudinal relationship of baseline functional brain networks with intentional weight loss in older adults

Burdette

Bahrami

Laurienti

et al. 2022

Self Cite

Objective:The goal of this study was to determine whether the degree of weight loss after 6 months of a behavior-based intervention is related to baseline connectivity within two functional networks (FNs) of interest, FN1 and FN2, in a group of older adults with obesity.Methods: Baseline functional magnetic resonance imaging data were collected following an overnight fast in 71 older adults with obesity involved in a weight-loss intervention. Functional brain networks in a resting state and during a food-cue task were analyzed using a mixed-regression framework to examine the relationships between baseline networks and 6-month change in weight.Results: During the resting condition, the relationship of baseline brain functional connectivity and network clustering in FN1, which includes the visual cortex and sensorimotor areas, was significantly associated with 6-month weight loss. During the food-cue condition, 6-month weight loss was significantly associated with the relationship between baseline brain connectivity and network global efficiency in FN2, which includes executive control, attention, and limbic regions. Conclusion:These findings provide further insight into complex functional circuits in the brain related to successful weight loss and may ultimately aid in developing tailored behavior-based treatment regimens that target specific brain circuitry.