The worldwide view of education has experienced a significant shift due to technical improvements and the COVID-19 epidemic. The pandemic’s disruption led to the adoption of contemporary technologies like blended learning and online learning by international educational institutions. Calls for converting educational material to electronic forms have arisen as there is a rising realization that conventional education must change to meet the job market’s needs. The benefits of innovative and traditional education may be combined via blended learning. As a result, the primary goal of this article is to review the research article with a systematic review as an added value. PRISMA is used to guide the review process. However, three databases were used: Scopus, Web of Science, and Google Scholar. According to the articles, this study’s findings investigated (1) existing knowledge gaps of blended learning; and (2) the effectiveness of blended learning within the UAE secondary schools. Nine articles were evaluated within a limited period of 2020 to 2023, two were qualitative research, five were quantitative, and two were mixed research. The findings showed the effectiveness of blended learning in UAE secondary schools; however, it needs more research, practical implementations, and experience to make blended learning successful. In addition, the issues and challenges of some factors that impact the effectiveness of blended learning are also discussed. The results of this study constitute a valuable contribution to the existing body of scholarly knowledge and have practical implications for educational policymakers, administrators, and instructors.