Wind resource assessment is a key factor for the development and implementation of wind farms with the purpose of generating green, eco-friendly and clean electricity. The Bolivian Andes, as a large dry region, represents an important source of renewable energy. However, the altitude and high wind energy resources of the Bolivian Andes require further knowledge and understanding of the wind energy resources. In this study, the GWA have been used to determine the total area available to install wind farms considering the protected areas, roads, cities and transmission lines. In addition, the Weather Research and Forecasting (WRF v3.8.1) model is employed to complement the results of the GWA based on the validation of WRF simulations with measurements from Qollpana wind farm. The main purpose is to estimate the wind power potential along the Bolivian Andes and its variability in time. The wind power simulations have been compared with the power generated by the Qollpana wind farm to verify the WRF’s performance. The wind power potential in the highlands of the Bolivian Andes could reach between 225 (WRF) and 277 (GWA) GW, distributed mainly over the Western and Eastern Cordillera of the Altiplano.