Empowering Women’s Health: Insights Into HPV Vaccination and the Prevention of Invasive Cervical Cancer

Rathod, Sachin; Potdar, Jyotsna; Gupta, Aishwarya; Sethi, Neha; Dande, Anubha

doi:10.7759/cureus.49523

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…This emphasizes the influential role of healthcare professionals in promoting vaccination and underscores the importance of accurate information dissemination by trusted sources. [28] Among participants who had not received the HPV vaccine, a substantial number (35.8%) expressed willingness to get vaccinated if provided the opportunity. However, a considerable portion (49.7%) had not yet decided citing limited knowledge about HPV and its vaccination, indicating a need for targeted educational interventions to address knowledge gaps and misconceptions about HPV and its vaccination.…”

Section: Discussionmentioning

confidence: 99%

HPV vaccine uptake, HPV infection and vaccination related knowledge and health beliefs among health sciences students in Coimbatore district, Tamil Nadu: An analytical cross-sectional study

Sanjay,

Narendranath,

Seetharaman

et al. 2024

Preprint

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Background: Human Papillomavirus (HPV) infection, a prevalent sexually transmitted infection, is the leading cause of cervical cancer. However, it is preventable. Objectives:To determine the prevalence of HPV vaccine uptake among health sciences students in Coimbatore district, Tamil Nadu; and to determine the levels of knowledge and health beliefs regarding HPV infection and vaccination. Methods:This was an analytical cross-sectional study conducted among health sciences students in Coimbatore district, Tamil Nadu between November 2022, and January 2023. Results: A total of 1139 participants of mean (SD) age 19.5 years (1.5) were enrolled. More than two thirds were females (68.1%). The prevalence of HPV vaccine uptake was 5.0%; of which 87.6% were recommended by doctors. Of the 1082 participants who had not taken HPV vaccine, 35.8% were willing to take if provided free of cost. Only 4.8% participants had adequate overall knowledge regarding HPV infection and vaccination; with 9.8% having adequate general HPV knowledge, 29.3% having adequate HPV vaccine knowledge, 4.0% having adequate HPV testing, and 4.0% having adequate HPV vaccine availability knowledge. One in five (19.4%) participants had favourable/appropriate health beliefs regarding HPV infection and its vaccination – with 43.5% having perceived benefits, 39.5% having perceived sensitivity, 34.6% having perceived severity, and 19.8% having perceived obstacles. The overall HPV – Knowledge scale scores (HPV-KS) and overall HPV infection and vaccine health belief model scale (HBMS-HPVV) scores had a significant positive correlation (r=0.251; p=<0.001). Participants with employed mothers, from upper socioeconomic status, with history of HPV vaccination in the family, and uptake of HPV vaccine for self were associated with significantly higher overall HPV-KS scores. Similarly, overall HBMS-HPVV scores were significantly higher among participants from urban family residence, with literate mothers, and from upper socioeconomic status. Conclusion: The findings underscore the importance of multifaceted interventions that address knowledge gaps, dispel myths or misconceptions, and tailor messaging to resonate with diverse cultural and socioeconomic backgrounds.

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Section: Discussionmentioning

confidence: 99%

HPV vaccine uptake, HPV infection and vaccination related knowledge and health beliefs among health sciences students in Coimbatore district, Tamil Nadu: An analytical cross-sectional study

Sanjay,

Narendranath,

Seetharaman

et al. 2024

Preprint

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Human Papillomavirus (HPV) Detection and Genotype Correlation with Cervical Lesions at the University Teaching Hospital of Kigali, Rwanda

Mbabazi,

Munyemana,

Mukashema

et al. 2024

Preprint

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Background Cervical cancer remains a major health issue, especially in low- and middle- income countries (LMICs), with Human papillomavirus (HPV) infection serving as the primary precursor. Despite global efforts to combat cervical cancer, including vaccination, a critical knowledge gap persists regarding HPV prevalence, genotype distribution, and their correlation with cervical lesions in women from poor resource areas. This study assessed the prevalence of HPV infection, identified the most common HPV genotypes, and evaluated their correlation with cervical lesions among women attending the University Teaching Hospital of Kigali (CHUK), Rwanda. Methods This cross-sectional retrospective study initially involved 473 women who were screened for HPV infection. Cervical lesions were further evaluated in 74 HPV-positive women. Clinical and demographic data, HPV genotypes, and cervical lesion information were collected and analyzed for these 74 HPV-positive women. Data were analysed using IBM SPSS Statistics version 29.0.2. and significance level was set at 0.05. Results HPV detection rate was 74/473 (15.6%), with a concentration among women aged 41–45 years (29.7%). Notably, 16/74 (21.6%) of HPV-positive women were also human immunodeficiency virys (HIV) positive. HPV genotypes 16 and 18 were the most prevalent with 14(8.3%) each. Cytological analysis revealed 5.2% precancerous lesions, while histological examination showed 33.3% precancerous lesions and 33.3% invasive carcinomas. Women with high risk HPV (HR-HPV) infections demonstrated a 2.5-fold increased risk of developing cancerous lesions compared to those with low risk HPV (LR-HPV) infections (95% CI: 1.637–4.56, p = 0.0028). Conclusion This study highlights the varied distribution of HPV genotypes among Rwandan women and a link between HR-HPV types and cervical lesions. The findings emphasize the need for tailored cervical cancer prevention strategies, including targeted surveillance, vaccination, and enhanced screening in Rwanda and similar resource-limited settings. Clinical Trial Number: not applicable

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Assessment of Awareness and Acceptance of the Human Papillomavirus Vaccine among Women in Saudi Arabia: A Community-Based Survey

Alrashidi,

Ali,

Miskeen

et al. 2024

Clin. Exp. Obstet. Gynecol.

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Background: Globally, cervical cancer represents a major public health concern. The Human Papillomavirus (HPV) vaccine serves as a primary preventive strategy against cervical cancer. This study aimed to assess the HPV vaccine awareness and acceptability (HPVVAA) among women in Saudi Arabia. Methods: This study employed a mixed-methods approach, combining both qualitative and quantitative data to assess HPVVAA among women in Saudi Arabia. A national survey was conducted with a diverse sample of 640 Saudi women, aged 18 to 65, representing both urban and rural areas. Data collection involved structured questionnaires, including both closed-ended and open-ended questions, distributed online and via paper-based self-administration. Descriptive statistics summarized demographic characteristics, while inferential statistics and logistic regression were used to identify associations between variables. Thematic content analysis of the open-ended responses was conducted to explore recurring themes related to awareness, acceptability, and potential barriers. Statistical significance was set at p < 0.05. Ethics approval and written informed consent were obtained prior to participants’ involvement in the study. Results: A total of 640 women participated in the study. The majority of participants were over 50 years old (31.2%), married (45.3%), and held a university or higher educational level (43.8%). Approximately 39.1% of participants had received the HPV vaccine, while 56.3% expressed willingness to accept it. Awareness of HPV and its link to cervical cancer was reported at 78.8% and 62.5%, respectively. The primary source of information (34.4%) was healthcare professionals. Positive attitudes toward vaccinations and favorable perceptions of the HPV vaccine’s safety and efficacy were prevalent among the respondents. Age (p < 0.01; odds ratio [OR]: 1.134; 95% confidence interval [95% CI]: 1.045–1.231) and marital status (p = 0.027; OR: 1.078; 95% CI: 1.007–1.153) were significant predictors of vaccine acceptance. Age was identified as a significant factor that influences awareness (p < 0.001; OR: 1.25; 95% CI: 1.10–1.42). Participants who were one year older were 1.25 times more likely to be aware of the HPV vaccine, with a 95% CI of 1.10 to 1.42 (p < 0.001). Participants with better healthcare access were more likely to be aware of the HPV vaccine (p < 0.001; OR: 1.30; 95% CI: 1.15–1.47). Conclusions: The study found a significant HPVVAA among women in Saudi Arabia. However, there is room for improvement in vaccine uptake, particularly in addressing barriers such as accessibility, affordability, and fear of side effects. Targeted communication strategies and public health initiatives are recommended to enhance HPVVAA and uptake, ultimately contributing to the global goal of cervical cancer prevention and control.

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Empowering Women’s Health: Insights Into HPV Vaccination and the Prevention of Invasive Cervical Cancer

Cited by 6 publications

References 34 publications

HPV vaccine uptake, HPV infection and vaccination related knowledge and health beliefs among health sciences students in Coimbatore district, Tamil Nadu: An analytical cross-sectional study

HPV vaccine uptake, HPV infection and vaccination related knowledge and health beliefs among health sciences students in Coimbatore district, Tamil Nadu: An analytical cross-sectional study

Human Papillomavirus (HPV) Detection and Genotype Correlation with Cervical Lesions at the University Teaching Hospital of Kigali, Rwanda

Assessment of Awareness and Acceptance of the Human Papillomavirus Vaccine among Women in Saudi Arabia: A Community-Based Survey

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