EMT in salivary gland tumors: the expression of microRNAs miR-155 and miR-200c is associated with clinical-pathological parameters

Kerche, Leandra Ernst; Sousa, Elen Alves de; Squarize, Cristiane H.; Oliveira, Katia Klug; Marchi, Fábio Albuquerque; Bettim, Bárbara Beltrame; Kowalski, Luiz Paulo; Soares, Fernando Augusto; Lourenço, Sílvia Vanessa; Coutinho‐Camillo, Cláudia Malheiros

doi:10.1007/s11033-021-07033-1

Cited by 10 publications

(12 citation statements)

References 46 publications

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“…When PA was compared to NGS, 37 miRNAs were highly expressed and 11 miRNAs were downregulated, specially miR-21, miR-29a, miR-34a, and miR-140-5p. 1,15,27,30,31 In our study, residual PA demonstrated CN loss in miR-21 and miR-34a genes and CN gain in miR-140, which agrees with the expected expression pattern observed in the literature in PA. Additionally, the CXPA group had CN loss of the miR-34a and miR-140 genes and CN gain in the miR-21, miR-29a, miR-34a, and miR-140 genes. The comparison of PA with other malignant SGTs was performed by Ramachandran and colleagues (2014) 26 and Ianez in 2016.…”

Section: Comparison Of Cnas In Mirna Genes Of Our Study and Mirna Exp...supporting

confidence: 91%

“…According to the literature, only nine studies investigated the expression of miRNAs in PA using the reverse transcription polymerase chain reaction technique. 1,15,[26][27][28][29][30][31][32][33] The PAs were compared with normal salivary glands (NSG), CXPA, residual PA, ACC, EMC, MEC, and CXPA. A summary of the main findings can be found in Supplementary Material Table S2.…”

Section: Comparison Of Cnas In Mirna Genes Of Our Study and Mirna Exp...mentioning

confidence: 99%

“…Salivary gland tumors (SGTs) are a heterogeneous group of benign and malignant lesions constituting approximately 3%-5% of all head and neck neoplasms. 1 In this context, Pleomorphic Adenoma (PA) represents about 60%-70% of these tumors, 2,3 of which about 6% may undergo malignant transformation to a carcinoma ex pleomorphic adenoma (CXPA). 4,5 Residual areas of PA can be found interspersed with the malignant part of the carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

Kimura,

Scarini,

Lavareze

et al. 2024

Head & Neck

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ObjectiveThis study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA).Materials and MethodsWe analyzed 13 PA, 4 RPA, 29 CXPA, and 14 residual PA using Nexus Copy Number Discovery software. The miRNAs genes affected by CNAs were evaluated based on their expression patterns and subjected to pathway enrichment analysis.ResultsAcross the groups, we found 216 CNAs affecting 2261 miRNA genes, with 117 in PA, 59 in RPA, 846 in residual PA, and 2555 in CXPA. The chromosome 8 showed higher involvement in altered miRNAs in PAs and CXPA patients. Six miRNA genes were shared among all groups. Additionally, miR‐21, miR‐455‐3p, miR‐140, miR‐320a, miR‐383, miR‐598, and miR‐486 were prominent CNAs found and is implicated in carcinogenesis of several malignant tumors. These miRNAs regulate critical signaling pathways such as aerobic glycolysis, fatty acid biosynthesis, and cancer‐related pathways.ConclusionThis study was the first to explore CNAs in miRNA‐encoding genes in the PA‐CXPA sequence. The findings suggest the involvement of numerous miRNA genes in CXPA development and progression by regulating oncogenic signaling pathways.

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Section: Comparison Of Cnas In Mirna Genes Of Our Study and Mirna Exp...supporting

confidence: 91%

Section: Comparison Of Cnas In Mirna Genes Of Our Study and Mirna Exp...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

Kimura,

Scarini,

Lavareze

et al. 2024

Head & Neck

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“…In salivary gland tumor tissue samples, miR-155, miR-200c, miR-9, miR-138, and miR-200c were differentially expressed in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (ACC). The obtained results show that the EMT transformation of salivary gland tumors is controlled by different transcriptional regulators [142]. These miRNAs targeting non-transcription factors to modulate EMT in major cancers are listed in Table 2.…”

Section: Mirnas Regulate Emt In Other Cancersmentioning

confidence: 92%

The Role of MicroRNA in the Regulation of Tumor Epithelial–Mesenchymal Transition

Feng

Liu

et al. 2022

Cells

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Consistently, the high metastasis of cancer cells is the bottleneck in the process of tumor treatment. In this process of metastasis, a pivotal role is executed by epithelial–mesenchymal transition (EMT). The epithelial-to-mesenchymal transformation was first proposed to occur during embryonic development. Later, its important role in explaining embryonic developmental processes was widely reported. Recently, EMT and its intermediate state were also identified as crucial drivers in tumor progression with the gradual deepening of research. To gain insights into the potential mechanism, increasing attention has been focused on the EMT-related transcription factors. Correspondingly, miRNAs target transcription factors to control the EMT process of tumor cells in different types of cancers, while there are still many exciting and challenging questions about the phenomenon of microRNA regulation of cancer EMT. We describe the relevant mechanisms of miRNAs regulating EMT, and trace the regulatory roles and functions of major EMT-related transcription factors, including Snail, Twist, zinc finger E-box-binding homeobox (ZEB), and other families. In addition, on the basis of the complex regulatory network, we hope that the exploration of the regulatory relationship of non-transcription factors will provide a better understanding of EMT and cancer metastasis. The identification of the mechanism leading to the activation of EMT programs during diverse disease processes also provides a new protocol for the plasticity of distinct cellular phenotypes and possible therapeutic interventions. Here, we summarize the recent progress in this direction, with a promising path for further insight into this fast-moving field.

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“…These proteins promote invasion and metastasis. Conversely, c-kit expression was associated with perineural infiltration and tumor grade in AdCC [ 56 , 150 ]. Pan-cancer analysis has shown an activating IGF-1R hotspot non-frameshift insertions, which were significantly enriched in AdCC.…”

Section: Novel Targets and Biomarkersmentioning

confidence: 99%

The Therapeutic Landscape of Salivary Gland Malignancies—Where Are We Now?

Cleymaet

Vermassen

Coopman

et al. 2022

IJMS

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Salivary gland malignancies (SGMs) account for less than 5% of new diagnoses in head and neck tumors. If feasible, surgery is the preferred treatment modality. Nevertheless, some malignancies have a tendency of recurrence, with possible distant metastasis. Alternative treatment strategies, such as primary radiation or chemotherapeutics, often present low response rates. As a result, there is an unmet need for novel therapeutic approaches. Nowadays, target-based therapies (e.g., small inhibitors and immunotherapy) are used by the medical oncologist for possible treatment of advanced SGMs. Based on recent published trials, some novel treatments may provide additional disease control for some patients. However, sample sizes are small, the general findings are unsatisfactory, and a lot of uncertainties remain to be elucidated. Nevertheless, research shows that patients do not benefit from blind administration of systemic treatments and therefore a more personalized approach is highly needed. The aim of this review paper is to summarize the most recent advances in the biological understanding and molecular pathways of salivary gland cancers the association of these pathways with the current treatments used and their implications for more personalized targeted-based therapies.

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EMT in salivary gland tumors: the expression of microRNAs miR-155 and miR-200c is associated with clinical-pathological parameters

Cited by 10 publications

References 46 publications

MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

The Role of MicroRNA in the Regulation of Tumor Epithelial–Mesenchymal Transition

The Therapeutic Landscape of Salivary Gland Malignancies—Where Are We Now?

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