The review is devoted to describing how irradiation with neutrons, fast particles, and γ rays affects components of the diagnostic equipment for a thermonuclear reactor. It is shown that the radiation environment inside a reactor and in the space around it has a significant (and sometimes crucial) effect on the diagnostic instruments. Unfortunately, the available data on radiation effects do not allow us to reliably estimate the resistance of a particular diagnostic component to radiation damage from neutrons, γ rays, and other particles. Specifically, the shortage of data on the effect of 14-MeV thermonuclear neutrons is a major problem. Therefore, the radiation testing of both the instruments' individual components of the instruments and diagnostic systems as a whole is in particular of paramount importance.