Emulgel Emergent Systems: At a Glance for Topical Drug Delivery

VISHWAKARMA, GIRJESH; Panwar, Aakash Singh

doi:10.22159/ajpcr.2022.v15i3.43876

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…Emulgels have several disadvantages like poor absorption of large particle size through the skin. Some drugs have poor permeability through the skin also, skin irritation or allergic reaction may occur [32] .…”

Section: Figure (1):schematic Presentation For Release Of Active Ingr...mentioning

confidence: 99%

An overview of emulgels for topical application

Jabbar

Ali

2023

AJPS

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In recent years, gels have been preferentially used for cosmetics and topical pharmaceutical preparations due to their favorable characteristics, such as being greaseless, readily spreadable and easily removable. However, one obstacle that faced it was the inability to enclose hydrophobic compounds. Therefore, a novel approach was developed to circumvent this limitation by mixing the gel with an emulsion, which led to creation of a new topical drug delivery system known as emulgel. Emulgel preserves all favorable features of gel and provides also dual release for drug, thus can be utilized effectively in controlling release and absorption of medication after topical application. Emulgel preparation requires coherent steps, this includes preparation of emulsion and gel and determining their mixing ratio. Finally, the prepared emulgels should be evaluated to ensure their suitability and efficacy for the topical application.

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Section: Figure (1):schematic Presentation For Release Of Active Ingr...mentioning

confidence: 99%

An overview of emulgels for topical application

Jabbar

Ali

2023

AJPS

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“…Vitamin D-3 promotes wound healing and can easily be included into the oil phase of an emulgel due to its lipophilic nature [8]. When combined with silver nanoparticles, it is thought to have a stronger therapeutic impact due to antibacterial effect of silver [9,10]. Emulgel-based topical medication delivery is needed in this work because a silver nanoparticles and vitamin D-3 coupled emulgel is not yet available.…”

Section: Introductionmentioning

confidence: 99%

Design, Development and Improvement of an Emulgel Containing Silver Nanoparticles and Vitamin D-3 for Its Potential to Accelerate the Healing of Wound

YADAV,

PANDEY,

KUKKAR

2024

Int J App Pharm

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Objective: The aim of this research work was to prepare a topical emulgel based dosage form incorporated with vitamin D-3 and silver nanoparticles to reduce the wound healing time in any kind of wound. Methods: Central Composite Design (CCD) was applied for the optimization of emulgel by using Design expert software. Three responses (pH, viscosity, and in vitro drug release) and two factors (Carbopol concentration and stirring duration) were chosen, and Statistical Analysis of Variance (ANOVA) revealed that all the factors were significantly affecting the responses. Silver Nanoparticles (SNPs) was prepared with Green Tea Extract (GTE) and evaluated for particle size, Poly Dispersity Index (PDI), zeta potential and Fourier Transform Infra-red (FTIR) spectroscopy and revealed that SNPs of desired range and stability have been synthesized. Here excision wound model was used to evaluate the wound healing activity of formulation in vivo. Results: Maximum in vitro release 88.2±2.1 has shown by the optimized formulation F13, pH and viscosity were also found in optimum range i.e., 6.2±0.4 and 1672±33 respectively, followed by Korsmeyer and Peppas model. Total eight groups were designed for animal study and silver sulphadiazine was used as marketed formulation. F13 formulation was further evaluated for in vivo data, it was revealed that emulgel loaded with high dose of vitamin D-3 along with silver nanoparticles has shown 100.5±1.7% wound contraction, while marketed formulation has shown 103.7±1.1% wound contraction, which was much similar with test formulation. Cytotoxic cell study was done using assay on chicken egg, formulation has not shown any cytotoxic behaviour like haemolysis and cell damage on chick embryo’s blood vessels. Accelerated stability study of the optimized formulation was also performed to check whether the formulation was stable or not and it was revealed that optimized formulation was found stable for the period of six months. Conclusion: It was revealed that emulgel loaded with high dose of vitamin D-3 and SNPs found suitable to accelerate wound healing and showed almost similar response in wound contraction on comparison with marketed formulation. This emulgel promised to controlled the delivery of the drug for the longer duration.

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Technical and Patent Perspective on Film Forming Topical Sprays

DEHGHAN,

P. RAJPUT

2024

Int J Pharm Pharm Sci

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Film-forming systems were a viable option for topical and transdermal medication administration in the present study. Medication administered via the skin serves two purposes: topical treatment of skin disorders and transdermal drug absorption into the circulation. Apart from the ease of self-administration, the topical route provides a broad and diverse surface and functions as a substitute for oral and hypodermic injection drug delivery routes. Existing dosage forms, such as creams, patches, and ointments, have several drawbacks. In addition to being unsightly, patches can be painful to put on curved surfaces, create discomfort while peeling off, and most often cause skin irritation because of their occlusive qualities, which block sweat ducts and prevent perspiration from evaporating from the skin surface. This review encompasses the mechanism of polymers, such as ethyl cellulose and Eudragit types, plasticizers, and penetration enhancers utilized in film formation. Overall, polymeric film-forming sprays exhibit substantial potential for the convenient administration of antibiotics and antiseptics to treat bacterial, fungal, and viral skin infections. The application of topical medication is thought to result in both local and systemic effects. The physicochemical characteristics of the medication and patient adherence determine how well the topical treatment works. Poor permeability and poor adherence to the skin are some of the disadvantages of conventional pharmaceutical formulations for topical and dermatological administration. The development of medication delivery technologies intended for topical administration to the skin includes the use of topical film-forming systems.

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Emulgel Emergent Systems: At a Glance for Topical Drug Delivery

Cited by 3 publications

References 53 publications

An overview of emulgels for topical application

An overview of emulgels for topical application

Design, Development and Improvement of an Emulgel Containing Silver Nanoparticles and Vitamin D-3 for Its Potential to Accelerate the Healing of Wound

Technical and Patent Perspective on Film Forming Topical Sprays

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