Emulgels

Sharma, V.; Nayak, Suraj Kumar; Paul, Suprio R.; Choudhary, B.C.; Ray, Sirsendu Sekhar; Pal, Kunal

doi:10.1016/b978-0-08-102179-8.00009-0

Cited by 13 publications

(12 citation statements)

References 32 publications

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“…The formulation compositions are shown in Table 2 . Each formulation was prepared as a single batch of 20 g. The formulation was fabricated using the O/W hot homogenization method, and the method of preparation is explained briefly in three steps, 1–3 [ 36 , 37 ].…”

Section: Methodsmentioning

confidence: 99%

“…An amount of 0.5% Carbopol ETD 2020 was added to the rest of the 60% Milli-Q water, and it was neutralized to pH 5.5, with 1% NaOH solution, to form a gel at room temperature under continuous homogenization. The preformed emulsion was added dropwise to the gel base under continuous stirring at room temperature to form the nano-emulsion-loaded gel known as nano-emulgel (CF018 emulgel) [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

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Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation

et al. 2023

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The current study aimed to develop a topical emulgel of dasatinib (DTB) for rheumatoid arthritis (RA) treatment to reduce systemic side effects. The quality by design (QbD) approach was employed to optimize DTB-loaded nano-emulgel using a central composite design (CCD). Emulgel was prepared using the hot emulsification method, and then the particle size (PS) was reduced using the homogenization technique. The PS and % entrapment efficiency (% EE) were found to be 172.53 ± 3.33 nm (0.160 ± 0.014 PDI) and 95.11 ± 0.16%, respectively. The nano-emulsion (CF018 emulsion) in vitro drug release profile showed sustained release (SR) up to 24 h. MTT assay results from an in vitro cell line study revealed that formulation excipients had no effect, whereas emulgel showed a high degree of internalization. Furthermore, emulgel treatment significantly reduced LPS-induced TNF-α production in RAW 264.7 cells. The spherical shape was depicted in FESEM images of optimized nano-emulgel (CF018 emulgel) formulation. Ex vivo skin permeation was significantly increased when compared to the free drug-loaded gel (FDG). In vivo data revealed that the optimized CF018 emulgel is a non-irritant and is safe. In terms of paw swelling, the FCA-induced arthritis model demonstrated that the CF018 emulgel reduced paw swelling percentage compared to adjuvant-induced arthritis (AIA) control group. Following clinical testing in the near future, the designed preparation could be a viable alternative treatment for RA.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation

et al. 2023

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“…There are various nano-emulgel preparation methods reported based on the order of mixing of oil and aqueous phase [ 136 ]. Lupi et al (2014) as illustrated in Figure 3 A solubilized the drug in the oil phase and gelling agent in the water phase separately.…”

Section: Preparation Of Nano-emulgelmentioning

confidence: 99%

Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery

et al. 2023

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Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated preparation of different systems aims to deal with these limitations. The novel system prepared by the incorporation of nano-emulsion into gel improves stability and enables drug delivery for both immediate and controlled release. The focus on nano-emulgel has also increased due to its ability to achieve targeted delivery, ease of application, absence of gastrointestinal degradation or the first pass metabolism, and safety profile. This review focuses on the formulation components of nano-emulgel for topical drug delivery, pharmacokinetics and safety profiles.

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“…The properties of emulgels such as non-toxic, non-irritating, non-sensitizing, and non-comedogenic are mainly associated with the emulgel composition. The primary requirement for the formulation of an emulgel is the appropriate selection of the oil phase, emulsifier, and gelling agent [ 5 , 20 ].…”

Section: Formulation Of Emulgelmentioning

confidence: 99%

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Milutinov,

Krstonošić,

Ćirin

et al. 2023

Polymers

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Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of emulsion and gel, which are particularly significant for the delivery of hydrophobic substances. However, the proper selection of main constituents determines the stability and efficacy of emulgels. Emulgels are dual-controlled release systems, where the oil phase is utilized as a carrier for hydrophobic substances and it determines the occlusive and sensory properties of the product. The emulsifiers are used to promote emulsification during production and to ensure emulsion stability. The choice of emulsifying agents is based on their capacity to emulsify, their toxicity, and their route of administration. Generally, gelling agents are used to increase the consistency of formulation and improve sensory properties by making these systems thixotropic. The gelling agents also impact the release of active substances from the formulation and stability of the system. Therefore, the aim of this review is to gain new insights into emulgel formulations, including the components selection, methods of preparation, and characterization, which are based on recent advances in research studies.

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Emulgels

Cited by 13 publications

References 32 publications

Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation

Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation

Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

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