Emulgels Containing Carbopol 934P and Different Vegetable Oils for Topical Propolis Delivery: Bioadhesion, Drug Release Profile, and Ex Vivo Skin Permeation Studies

Santos, Rafaela Said dos; Vecchi, Camila Félix; Rosseto, Hélen Cássia; Silva, Jéssica Bassi da; Dano, Maria Eduarda Lima; Castro-Hoshino, Lidiane Vizioli de; Baesso, Mauro Luciano; Bruschi, Marcos Luciano

doi:10.1208/s12249-020-01748-3

Cited by 23 publications

(4 citation statements)

References 41 publications

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“…Emulgels result from an initial emulsification process followed by a gelation process, through gelation and/or crosslinking of the compounds that are present in the mixture. The amphiphilic behavior of the emulgels, which is potentiated by the hydrophilic and lipophilic affinities of its constituents, makes them a good option for the delivery of active agents, in a similar way to bigels [ 26 , 33 , 34 , 35 ]. In this way, emulgels have been at the forefront of the topical and transdermal delivery of drugs, due to characteristics such as their easy removability, emollient action, ease of extrusion, and spreadability.…”

Section: Hydrogels Oleogels Bigels and Emulgelsmentioning

confidence: 99%

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Pinto

Martins

Pastrana

et al. 2021

Gels

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Oleogels are semi-solid materials containing a large fraction of liquid oil entrapped in a network of structuring molecules. In the food industry, these formulations can be used to mimic fats and to deliver bioactive compounds. In the last decade, there has been increasing interest in these structures, not only from a scientific point of view, i.e., studying new molecules, methodologies for gelification, and new structures, but also from a technological point of view, with researchers and companies exploring these structures as a way to overcome certain challenges and/or create new and innovative products. One of the exciting applications of oleogels is the delivery of functional molecules, where the incorporation of oil-soluble functional compounds can be explored not only at the macroscale but also at micro- and nanoscales, resulting in different release behaviors and also different applications. This review presents and discusses the most recent works on the development, production, characterization, and applications of oleogels and other oleogel-based systems to deliver functional molecules in foods.

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Section: Hydrogels Oleogels Bigels and Emulgelsmentioning

confidence: 99%

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Pinto

Martins

Pastrana

et al. 2021

Gels

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“…Skin permeation and retention studies were investigated using porcine ear skin ( Said Dos Santos et al, 2020 ). The skin sample was properly cleaned and positioned between the receptor and donor compartments of Franz’s device.…”

Section: Methodsmentioning

confidence: 99%

Statistical modeling, optimization and characterization of andrographolide loaded emulgel for its therapeutic application on skin cancer through enhancing its skin permeability

V. L. Sirisha Mulukuri,

Kumar,

Dhara

et al. 2024

Saudi Pharmaceutical Journal

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“…Formulations composed of Carbopol 934P (C934P) and passion fruit (PF), sweet almond (SA), or andiroba (AO) oils were proposed as emulgels for the ethanolic propolis extract (PE) and the by-product of the propolis extraction (BPE). All the combinations provided proper permeation of PE and BPE phenolic compounds, with AO being the formulation with the best performance for PE by exhibiting prolonged release, permeation, and skin retention properties [76,77].…”

Section: Phenolic-rich Plant Extractsmentioning

confidence: 99%

In vitro diffusion of plant phenolics through the skin: A review update

Silva,

Rodrigues,

Bottoli

2023

Intern J of Cosmetic Sci

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ObjectiveExcessive skin exposure to deleterious environmental variables results in inflammation as well as molecular and cellular impairments that compromise its functionality, aesthetic qualities, and overall well‐being. The implementation of topical administration of antioxidants and other compounds as a method for preventing or reversing damage is a rational approach. Numerous phenolic compounds derived from plants have demonstrated capabilities such as scavenging free radicals and promoting tissue healing. However, the primary obstacle lies in effectively delivering these compounds to the specific place on the skin, and accurately forecasting their diffusion through the skin can assist in determining the most effective tactics. Hence, this article provides a comprehensive analysis of recent literature pertaining to the in vitro skin diffusion characteristics of plant phenolics. The aim is to gain a deeper understanding of their behaviour when present in various forms such as solutions, suspensions, and formulations.MethodThe data on plant extracts and isolated plant phenolic compounds in vitro skin diffusion assays published over the last six years were compiled and discussed.ResultsEven though the gold standard Franz diffusion cell is the most commonly used in the assessment of in vitro plant phenolic skin diffusion profiles, a plethora of skin models and assay conditions are reported for a variety of compounds and extracts in different vehicles.ConclusionThe presence of numerous models and vehicles poses a challenge in creating correlations among the existing data on plant phenolic compounds. However, it is possible to draw some general conclusions regarding molecular, vehicle, and skin characteristics based on the gathered information.

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Emulgels Containing Carbopol 934P and Different Vegetable Oils for Topical Propolis Delivery: Bioadhesion, Drug Release Profile, and Ex Vivo Skin Permeation Studies

Cited by 23 publications

References 41 publications

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Statistical modeling, optimization and characterization of andrographolide loaded emulgel for its therapeutic application on skin cancer through enhancing its skin permeability

In vitro diffusion of plant phenolics through the skin: A review update

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