Polymeric excipients are an integral part of any formulation as they enhance the loaded drug's stability, bioavailability, and controlled release profile. 1 They include natural (sodium alginate, gelatin, chitosan, Grewia gum), semi-synthetic (cellulose derivatives), synthetic (polyethylene glycols, poloxamers, polylactides, polyamides), and fermentation products (xanthan gum). 2 Gums and mucilages are polysaccharides or complex carbohydrates derived from various plant parts, microorganisms and marine algae. 3 Natural polysaccharide gums such as xanthan, tragacanth, acacia and Grewia gum are preferred over their synthetic counterparts because they are non-toxic, non-irritant, cost-effective, readily available and will not interact with the drug or other formulation and packaging components. 4 Grewia mollis (Fam. Tiliaceae), is an edible plant grown wild or cultivated in the Northern and middle belt region of Nigeria and Grewia gum is typically extracted from its inner stem bark. 5 Structurally, the gum is composed of glucose (67.14%), arabinose (12.71%), galactose (9.61%), rhamnose (6.2%), and xylose (2.72%) as the major monosaccharide. 5,6 It is reported to have an average molecular weight of 5925 kDa and polydispersity of 1.6, which is