2020
DOI: 10.18185/erzifbed.836484
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Emulsion Formulations of Indomethacine and Xylometazoline Hydrochloride for Intranasal Delivery

Abstract: Nasal administration has many advantages over parenteral and oral administration. Some drugs are ineffective when administered orally due to absorption and first pass metabolism. Therefore, if the aqueous solubility problem can be overcome, the intranasal route will be an alternative method for administration. In this study, emulsion formulation was proposed as a new approach in order to increase the duration of the indomethacinxylometazoline hydrochloride combination in the nose. The pH value of F1 and F2 emu… Show more

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