Emulsions as drug carriers for ophthalmic use

Muchtar, S.; Benita, Simon

doi:10.1016/0927-7757(94)02882-6

Cited by 15 publications

(7 citation statements)

References 11 publications

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“…Subsequently, the search for components that were non‐toxic for eye membranes and that were capable of forming kinetically stable nanoemulsions increased. Lecithins have long been used as one of the major emulsifiers in the preparation of ocular nanoemulsions . These emulsifiers are naturally occurring and show an affinity to cellular membranes because they contain a mixture of phospholipids, which are the molecules that comprise the cellular membrane.…”

Section: Delivery Systemsmentioning

confidence: 99%

Topical delivery of ocular therapeutics: carrier systems and physical methods

Souza

Dias

Pereira

et al. 2014

Journal of Pharmacy and Pharmacology

117

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Objective The basic concepts, major mechanisms, technological developments and advantages of the topical application of lipid-based systems (microemulsions, nanoemulsions, liposomes and solid lipid nanoparticles), polymeric systems (hydrogels, contact lenses, polymeric nanoparticles and dendrimers) and physical methods (iontophoresis and sonophoresis) will be reviewed. Key findings Although very convenient for patients, topical administration of conventional drug formulations for the treatment of eye diseases requires high drug doses, frequent administration and rarely provides high drug bioavailability. Thus, strategies to improve the efficacy of topical treatments have been extensively investigated. In general, the majority of the successful delivery systems are present on the ocular surface over an extended period of time, and these systems typically improve drug bioavailability in the anterior chamber whereas the physical methods facilitate drug penetration over a very short period of time through ocular barriers, such as the cornea and sclera. Summary Although in the early stages, the combination of these delivery systems with physical methods would appear to be a promising tool to decrease the dose and frequency of administration; thereby, patient compliance and treatment efficacy will be improved.

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Section: Delivery Systemsmentioning

confidence: 99%

Topical delivery of ocular therapeutics: carrier systems and physical methods

Souza

Dias

Pereira

et al. 2014

Journal of Pharmacy and Pharmacology

117

View full text Add to dashboard Cite

show abstract

“…The mean droplet size was 100±20 nm. The mean zeta potential of the emulsion was -31 mV, a surface charge preventing droplet coalescence upon random collisions or upon steam sterilization over a varying range of temperatures [28].…”

Section: Submicron Emulsion Evaluationmentioning

confidence: 99%

“…Stability and sterility assessment. Long-term stability studies of the HU-211 emulsion have been conducted at 4°C, 23°C and 37°C, testing HU-211 content and any physical changes (emulsion droplet size, zeta potential, creaming and pH) that might occur in the emulsion during storage [28]. Sterility of the emulsion was assessed using the Bactec 46 apparatus (Johnson Laboratories, Towson, Md.)…”

Section: Emulsion Evaluationmentioning

confidence: 99%