En bloc liver and pancreas transplantation after total pancreatectomy with autologous Islet transplantation

Generette, Gabriela S.; Bachul, Piotr J.; Gołąb, Karolina; Basto, Lindsay; Pyda, Jordan; Borek, Peter; Tibudan, Martin; Anteby, Roi; Perea, Laurencia; Charlton, Michael; Perez‐Gutierrez, Angelica; Jayant, Kumar; Lucander, Aaron; Matthews, Jeffrey B.; Millis, J. Michael; Fung, John; Witkowski, Piotr

doi:10.31373/ejtcm/130187

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Subsequently, the patient developed alcohol related acute liver failure and en-bloc liver and pancreas transplantation was performed to replace the failing liver with engrafted islets. A successful pancreas transplantation was performed to resolve his life-threatening severe hypoglycemic episodes [98].…”

Section: Pancreas Transplants As Part Of Cluster Transplants For Uppe...mentioning

confidence: 99%

Pancreas Transplantation for the Treatment of Pancreatic Exocrine Disorders

Gruessner,

Laftavi,

Pankewycz

et al. 2024

J Surgery

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Pancreas transplantation is mostly performed to cure diabetes mellitus. However, patients with chronic pancreatitis, cystic fibrosis, benign pancreatic tumors or patients with other exocrine disorders of the pancreas can also be candidates for a pancreas transplant in combination with a kidney, liver or lung or for a pancreas transplant alone. With improvement in surgical techniques and immunosuppressive therapy, pancreas transplant outcomes have improved significantly over the past decade. Mounting evidence supports pancreas transplantation for the treatment of exocrine disorders as an important therapeutic option to restore both endocrine and exocrine function of the pancreas. Patient and graft survival rates are similar to those for pancreas transplants in diabetic patients. A successful pancreas transplant is also more cost efficient and puts less burden on health care spending. However, the risk of immunosuppression and surgery should be carefully evaluated and discussed with the patient. In this review article, we discuss pancreas transplantation for pancreatic exocrine disorders: indications, other treatment options, and outcomes.

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Section: Pancreas Transplants As Part Of Cluster Transplants For Uppe...mentioning

confidence: 99%