“En Face” Optical Coherence Tomography Imaging in Type 2 Idiopathic Macular Telangiectasia

Wolff, Benjamin; Basdekidou, Chrysanthi; Vasseur, Vivien; Sahel, José‐Alain; Gaudric, Alain; Mauget‐Faÿsse, Martine

doi:10.1097/iae.0000000000000208

Cited by 15 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,11,13,14,16–18,26 While the pathophysiology of MacTel type 2 remains uncertain, it is hypothesized to be linked to Müller cell death or dysfunction, which leads to the resulting photoreceptor loss (and thus EZ disruption) and juxtafoveal capillary proliferation. 1,18 …”

Section: Discussionmentioning

confidence: 99%

OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study

Runkle

Srivastava

Schachat

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PurposeTo evaluate alterations on optical coherence tomography angiography (OCT-A) and quantitatively assess alterations in the ellipsoid zone (EZ) in eyes with macular telangiectasia type 2 (MacTel type 2).MethodsThe Observational Assessment of Visualizing and Analyzing Vessels With Optical Coherence Tomography Angiography in Retinal Diseases study is an institutional review board-approved prospective, observational study investigating OCT-A in macular disease. Patients underwent spectral-domain (SD)-OCT and OCT-A imaging at a single visit. SD-OCT data were analyzed using a novel OCT EZ-mapping software to obtain linear, area, and volumetric measurements of the EZ-retinal pigment epithelium (RPE) complex across the macular cube. OCT-A retinal capillary density was measured using the Optovue Avanti split-spectrum amplitude-decorrelation angiography algorithm. EZ-RPE parameters were compared to age-matched, sex-matched controls.ResultsFourteen eyes of seven patients (mean age, 59 ± 6.5 years) were analyzed. Mean visual acuity was 20/45 (range, 20/20–20/150). EZ-RPE central foveal mean thickness was 27.8 ± 6.7 μm, EZ-RPE central foveal thickness was 22.1 ± 21.6 μm, EZ-RPE central foveal area was 0.17 ± 0.04 mm2, and EZ-RPE central subfield volume was 0.017 ± 0.012 mm3. Each of these measurements was significantly inversely correlated with visual acuity (P < 0.02). In addition, all of these measurements were significantly reduced compared to controls (all P ≤ 0.005). OCT-A showed a reduced parafoveal vessel density of 50.8% temporally compared to 53.8% nasally (P = 0.01) in the superficial vascular plexus. In the deep vascular plexus, similar findings were noted with a parafoveal vessel density of 56.7% temporally and 58.8% nasally (P = 0.01).ConclusionsAbnormalities in EZ-RPE thickness, area, and volume are correlated with visual acuity in MacTel type 2, and may provide quantitative markers to measure disease progression and treatment response. OCT-A was a useful adjunct for determining disease severity.

show abstract

Section: Discussionmentioning

confidence: 99%

OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study

Runkle

Srivastava

Schachat

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Moreover, this method is robust to small segmentation inaccuracies. At the same time, en face OCT requires image processing techniques that deal with the numerous confounding shadow artifacts unrelated to the atrophy [21, 22, [43][44][45], such as the large vessel shadow inaccurately segmented in [ Fig. 9 (DR3)].…”

Section: Discussionmentioning

confidence: 99%

Automated detection of photoreceptor disruption in mild diabetic retinopathy on volumetric optical coherence tomography

Wang¹,

Camino²,

Zhang³

et al. 2017

Biomed. Opt. Express

View full text Add to dashboard Cite

Diabetic retinopathy is a pathology where microvascular circulation abnormalities ultimately result in photoreceptor disruption and, consequently, permanent loss of vision. Here, we developed a method that automatically detects photoreceptor disruption in mild diabetic retinopathy by mapping ellipsoid zone reflectance abnormalities from en face optical coherence tomography images. The algorithm uses a fuzzy c-means scheme with a redefined membership function to assign a defect severity level on each pixel and generate a probability map of defect category affiliation. A novel scheme of unsupervised clustering optimization allows accurate detection of the affected area. The achieved accuracy, sensitivity and specificity were about 90% on a population of thirteen diseased subjects. This method shows potential for accurate and fast detection of early biomarkers in diabetic retinopathy evolution.

show abstract

“…Progression of the disease is characterised by shrinkage of the outer retinal layers and reduction in the central foveal thickness (CFT) 8. En face OCT also enables visualisation of the pigment plaques and new vessels in the various retinal layers along with the extent of associated exudation 5 9…”

Section: Introductionmentioning

confidence: 99%

Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography

et al. 2016

View full text Add to dashboard Cite

show abstract

“En Face” Optical Coherence Tomography Imaging in Type 2 Idiopathic Macular Telangiectasia

Abstract: En face OCT is a noninvasive and reproducible technique that helps to better assess and follow up retinal and choroidal processes in Type 2 macular telangiectasia.

Cited by 15 publications

References 8 publications

OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study

OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study

Automated detection of photoreceptor disruption in mild diabetic retinopathy on volumetric optical coherence tomography

Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography

Contact Info

Product

Resources

About