Modeling and simulation represent an essential part of overall systems engineering. Complex engineering systems are composed of many heterogeneous components often modeled and simulated employing different languages and environments, and often by different organizations; thus, demands for interoperability are getting increased. Model‐driven engineering (MDE) has been demonstrated to be an advancement in software engineering: existing software in several domains today benefits from abstraction and automation during the system development process. Although these techniques are now highly advanced, many industries may require considerable effort before fully benefiting from them. This article reports on a case study carried out for 12 months within a company in the space industry domain. The goal of this empirical study is to investigate the adoption of MDE in supporting simulation models interoperability. The article identifies factors considered important for MDE adoption as well as obstacles that can be encountered in a real case. Researchers and practitioners may benefit from our findings typically when reusing models across different simulation environments, exchanging simulation models between different stakeholders, and seeking to improve simulation modeling practices.