Optimal operation and control, which can result in the global optimal operation performance of industrial processes, has been a hot topic in recent control strategy designs. However, existing control strategies, such as real-time optimization (RTO), dynamic real-time optimization (DRTO), and economic model predictive control (EMPC), have their own limitations, and they can only generate sub-optimal operation performance. In order to further improve online global operation performance, a new kind of control strategy named efficiency-oriented model predictive control (EfiMPC) is proposed in this paper. The aim of the EfiMPC is discussed first, and then, the ideal EfiMPC strategy with a nested structure is proposed, where the inner layer is the offline construction of an efficiency-oriented terminal region, and the outer layer is the direct optimization of the transient operation performance. This efficiency-oriented terminal region can guarantee a dynamic operation performance in the closed-loop perspective, and a better global operation performance can thus be obtained. A practical EfiMPC strategy, which replaces the offline construction of the efficiency-oriented terminal region with the online optimization of the average dynamic operation performance in the inner layer, is also proposed, and the recursive feasibility as well as the closed-loop stability of practical EfiMPC are discussed. Finally, a CSTR application was used to test the superiority of the proposed EfiMPC strategy, and the simulation results show that EfiMPC can obtain the best global operation performance compared with the other three control strategies; thus, the effectiveness of EfiMPC is demonstrated.