In recent years, Healthcare 4.0, the fourth healthcare revolution, has piqued the interest of numerous researchers around the world. Healthcare 4.0 is a relatively new term that has evolved from Industry 4.0 to meet diverse requirements in the healthcare domain. Healthcare 4.0 serves as a technological catalyst for accelerated growth by integrating cutting-edge industrial technologies. Despite the evolving nature of Healthcare 4.0 research, a complete and systematic survey of recent research on it has been scarce. Conspicuously, this study intends to present a systematic survey by investigating the recent trends, key constraints, and application areas of Healthcare 4.0. Further, a comprehensive survey of the research is used to identify the essential technologies required for the effective adoption of Healthcare 4.0. The research was conducted using the PRISMA methodology and an exhaustive search of all easily accessible libraries and academic repositories was made to obtain the relevant literature. At last, a diversity of outstanding issues are also presented to assist scholars and professionals who are interested in undertaking futuristic research in the current field.