Enamel Anti-Demineralization Effect of Orthodontic Adhesive Containing Bioactive Glass and Graphene Oxide: An In-Vitro Study

Lee, Seung-Min; Yoo, Kyung Hyeon; Yoon, Seog Young; Kim, In Ryoung; Park, Bong Soo; Son, Woo Sung; Ko, Ching‐Chang; Son, Sung Ae; Kim, Yong Il

doi:10.3390/ma11091728

Cited by 50 publications

(90 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This increase in microhardness occurs because GaMBN acts as a filler in the resin and its strength increases with its concentration. Moreover, there were no statistically significant differences between the bracket retention force and ARI of the GaMBN-containing resins, which has also been reported by previous studies [8][9][10][11]; therefore, GaMBN-containing resins are not expected to cause clinical problems when maintaining a fixed orthodontic appliance.…”

Section: Discussionsupporting

confidence: 83%

“…3released by GaMBN5 were consistent with the amounts required for remineralization during the 14 days of the pH cycle [8][9][10][11]19]. The greatest advantage of MBN is its pore structure, which makes it a functional material that can be used to transport various genes and drugs.…”

Section: Discussionsupporting

confidence: 54%

“…While there are conservative and prosthodontic treatments that can treat WSLs, these methods can damage natural teeth; thus, it is important to prevent WSLs before they occur [4]. Previous studies have developed preventive methods by adding biomaterials to the dental resins used to attach fixed orthodontic appliances [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…The anti-demineralization tests used to assess the remineralization effect of the GaMBN-containing resin (CF, CharmFill Flow, Dentkist, Seoul, South Korea) were based on methods previously reported in the literature, and were reviewed and approved by the Institutional Review Board of Pusan National University Dental Hospital (PNUDH-2018046) [8][9][10][11]. Each group of experiments used ten healthy premolar teeth-untreated enamel with no WSLs or other enamel defects-that had been extracted for orthodontic purposes.…”

Section: Anti-demineralization Propertiesmentioning

confidence: 99%

“…White spot legions on anterior teeth are considered unaesthetic as the demineralized enamel is often whiter than the surrounding enamel [6]; hence, clinicians have made several attempts to prevent the formation of WSLs [7]. For example, researchers have attempted to incorporate antibacterial agents in orthodontic adhesives in order to reduce the causative bacteria and thus prevent WSLs caused by orthodontic devices [8][9][10][11]. Gallium (III) has been used an antibacterial agent as it can mimic Fe (III) [12,13].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

In Vitro Effect of Gallium-Doped Bioactive Glass on Enamel Anti-Demineralization and Bond Strength of Orthodontic Resins

et al. 2019

Self Cite

View full text Add to dashboard Cite

White spot lesions (WSL) that occur on teeth after orthodontic appliances have been attached are caused by bacterial demineralization of the enamel surface. This study investigated the anti-demineralization effect of orthodontic resins containing mesoporous bioactive glass nanoparticles (MBN) doped with gallium, which has antibacterial activity, as well as MBN with increased calcium and phosphate contents as these ions can remineralize enamel. Resins (CF, CharmFill Flow, Dentkist, Seoul, South Korea) containing 1%, 3%, and 5% Ga-doped MBN (GaMBN) were characterized using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and isothermal tests, and their physical properties were measured in terms of Vickers microhardness, bracket retention force, and adhesive remnant index (ARI). Cell viability in the resins was confirmed by testing human dental pulp stem cells (hDPSCs), and ion release tests were performed after 1, 7, and 14 days to determine whether the resins released Ga3+, Ca2+, and PO43–. After 14 days, antibacterial activity was determined using Streptococcus mutans (S. mutans)—the bacteria that causes tooth decay—and the chemical remineralization effect was investigated using a cycle of acid–base solutions. The microhardness of the resins increased with GaMBN concentration whereas their bracket retention force, ARI, and cell viability remained unchanged. The bacterial activity of the 5%-GaMBN resin decreased after 24 and 48 h; however, the change in activity was not statistically significant. Anti-demineralization testing demonstrated that the degree of enamel demineralization decreased as the GaMBN concentration increased, which indicates that resins containing 5%-GaMBN may be viable orthodontic adhesives for preventing WSLs.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Anti-demineralization Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

In Vitro Effect of Gallium-Doped Bioactive Glass on Enamel Anti-Demineralization and Bond Strength of Orthodontic Resins

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Role of bioglass in enamel remineralization: Existing strategies and future prospects—A narrative review

2021

View full text Add to dashboard Cite

Enamel, once formed, loses the ability to regenerate due to the loss of the formative ameloblasts. It is subjected to constant damaging events due to exposure to external agents and oral microbiomes. An enamel remineralization process targets to replenish the lost ionic component of the enamel through a multitude of methods. Enamel remineralization is highly challenging as it has a complex organized hierarchical microstructure. Hydroxyapatite nanocrystals of the enamel vary in size and orientation along alignment planes inside the enamel rod. The inability of the enamel to remodel unlike other mineralized tissues is another substantial deterrent. One of the wellknown biomaterials, bioglass (BG) induces apatite formation on the external surface of the enamel in the presence of saliva or other physiological fluids. Calcium, sodium, phosphate, and silicate ions in BG become responsive in the presence of body fluids, leading to the precipitation of calcium phosphate. Studies have also demonstrated the bactericidal potential of BG against Streptococcus mutans biofilms. The anticariogenicity and antibacterial activity were found to be enhanced when BG was doped with inorganic ions such as F, Ag, Mg, Sr, and Zn. Due to the versatility of BG, it has been combined with a variety of agents such as chitosan, triclosan, and amelogenin to biomimic remineralization process. Key strategies that can aid in the development of contemporary enamel remineralization agents are also included in this review.

show abstract

Synergistic effect of graphene oxide/calcium phosphate nanofiller in a dentin adhesive on its dentin bond integrity and degree of conversion. A scanning electron microscopy, energy dispersive X‐ray spectroscopy, Fourier transform infrared, micro‐Raman, and bond strength study

Almutairi

Kattan

Binmahfooz

et al. 2021

Microscopy Res & Technique

View full text Add to dashboard Cite

The objective was to formulate and analyze a dentin adhesive incorporated with graphene oxide (GO) nanoparticle and calcium phosphate (CaP) composite. Methods comprising of scanning electron microscopy (SEM)–energy dispersive X‐ray spectroscopy (EDX), micro‐Raman spectroscopy, shear bond strength (SBS), and Fourier transform infrared (FTIR) spectroscopy were used to characterize nanoparticle composite, dentin bond toughness, degree of conversion (DC), and adhesive‐dentin interaction. Postsynthesis of GO nanoparticles, they were functionalized with CaP using standard process. The GO‐CaP composite was not added to experimental adhesive (negative control group, GO‐CaP‐0%), and added at 2.5 and 5 wt% to yield GO‐CaP‐2.5% and GO‐CaP 5% groups, respectively. Teeth were set to form bonded samples utilizing adhesives in three groups for SBS testing, with and without thermocycling. The homogenous diffusion of GO‐CaP composite was verified in the adhesive. Resin tags having standard penetrations were observed on SEM micrographs. The EDX analysis confirmed the occurrence of calcium, phosphorus, and carbon ions in the composite containing adhesives. The SBS test revealed highest mean values for GO‐CaP‐5% followed by GO‐CaP‐2.5%. The FTIR spectra verified the presence of apatite peaks and the micro‐Raman spectra showed characteristic D and G bands for GO nanoparticles. GO‐CaP composite in dentin adhesive may improve its bond strength. The addition of 5 wt% resulted in a bond strength that was superior to all other groups. GO‐CaP‐5% group demonstrated lower DC (to control), uniform distribution of GO and CaP composite within adhesive, appropriate dentin interaction, and resin tag formation.

show abstract

Enamel Anti-Demineralization Effect of Orthodontic Adhesive Containing Bioactive Glass and Graphene Oxide: An In-Vitro Study

Cited by 50 publications

References 22 publications

In Vitro Effect of Gallium-Doped Bioactive Glass on Enamel Anti-Demineralization and Bond Strength of Orthodontic Resins

In Vitro Effect of Gallium-Doped Bioactive Glass on Enamel Anti-Demineralization and Bond Strength of Orthodontic Resins

Role of bioglass in enamel remineralization: Existing strategies and future prospects—A narrative review

Synergistic effect of graphene oxide/calcium phosphate nanofiller in a dentin adhesive on its dentin bond integrity and degree of conversion. A scanning electron microscopy, energy dispersive X‐ray spectroscopy, Fourier transform infrared, micro‐Raman, and bond strength study

Contact Info

Product

Resources

About