Enamel-Calibrated Lamellar Bone Reveals Long Period Growth Rate Variability in Humans

Bromage, Timothy G.; Juwayeyi, Yusuf M.; Smolyar, I; Hu, Bin; Gómez, Santiago; Chisi, John

doi:10.1159/000324216

Cited by 23 publications

(24 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this concept, all previously proposed definitions of lamellation may be valid representing a considerable variability in the formation, structure and composition of lamellated bone. Furthermore, the thickness of the lamellae can vary considerably (Bromage et al , , ), thus local changes in fibre orientation in the non‐lamellated HOPB may appear as lamellae. Finally, the border between the first lamella and the non‐lamellated HOPB is not always distinct which is probably due to the same principles of formation of the two subunits on a cellular level.…”

Section: Review and Revision Promoted By The New Resultsmentioning

confidence: 99%

Rethinking the nature of fibrolamellar bone: an integrative biological revision of sauropod plexiform bone formation

2013

View full text Add to dashboard Cite

We present novel findings on sauropod bone histology that cast doubt on general palaeohistological concepts concerning the true nature of woven bone in primary cortical bone and its role in the rapid growth and giant body sizes of sauropod dinosaurs. By preparing and investigating longitudinal thin sections of sauropod long bones, of which transverse thin sections were published previously, we found that the amount of woven bone in the primary complex has been largely overestimated. Using comparative cellular and light-extinction characteristics in the two section planes, we revealed that the majority of the bony lamina consists of longitudinally organized primary bone, whereas woven bone is usually represented only by a layer a few cells thin in the laminae. Previous arguments on sauropod biology, which have been based on the overestimated amount, misinterpreted formation process and misjudged role of woven bone in the plexiform bone formation of sauropod dinosaurs, are thereby rejected. To explain the observed pattern in fossil bones, we review the most recent advances in bone biology concerning bone formation processes at the cellular and tissue levels. Differentiation between static and dynamic osteogenesis (SO and DO) and the revealed characteristics of SO- versus DO-derived bone tissues shed light on several questions raised by our palaeohistological results and permit identification of these bone tissues in fossils with high confidence. By presenting the methods generally used for investigating fossil bones, we show that the major cause of overestimation of the amount of woven bone in previous palaeohistological studies is the almost exclusive usage of transverse sections. In these sections, cells and crystallites of the longitudinally organized primary bone are cut transversely, thus cells appear rounded and crystallites remain dark under crossed plane polarizers, thereby giving the false impression of woven bone. In order to avoid further confusion in palaeohistological studies, we introduce new osteohistological terms as well as revise widely used but incorrect terminology. To infer the role of woven bone in the bone formation of fast-growing tetrapods, we review some aspects of the interrelationships between the vascularity of bone tissues, basal metabolic rate, body size and growth rate. By putting our findings into the context of osteogenesis, we provide a new model for the diametrical limb bone growth of sauropods and present new implications for the evolution of fast growth in vertebrates. Since biomechanical studies of bone tissues suggest that predominant collagen fibre orientation (CFO) is controlled by endogenous, functional and perhaps phylogenetic factors, the relationship between CFO and bone growth rate as defined by Amprino's rule, which has been the basis for the biological interpretation of several osteohistological features, must be revised. Our findings draw attention to the urgent need for revising widely accepted basic concepts of palaeohistological studies, and for a more integrativ...

show abstract

Section: Review and Revision Promoted By The New Resultsmentioning

confidence: 99%

Rethinking the nature of fibrolamellar bone: an integrative biological revision of sauropod plexiform bone formation

2013

View full text Add to dashboard Cite

show abstract

“…Daily appositional growth produces cross striations [56]. In addition to this short-range circadian rhythm, enamel also has a long periodic rhythm evident in layers called striae of Retzius, with a repeat interval made of multiples of the shorter-term pattern [57–59]. Rather than a mechanical function, conservation of the short-term pattern and the repeat interval are hypothesized to reflect a central biological timing mechanism [59].…”

Section: Discussionmentioning

confidence: 99%

Dynamic structure and composition of bone investigated by nanoscale infrared spectroscopy

et al. 2018

View full text Add to dashboard Cite

Bone is a highly organized tissue in which each structural level influences the macroscopic and microscopic mechanical behavior. In particular, the quantity, quality, and distribution of the different bone components, i.e. collagen matrix and hydroxyapatite crystals, are associated with bone strength or fragility. Common spectroscopic techniques used to assess bone composition have resolutions limited to the micrometer range. In this study, our aims were two-fold: i) to develop and validate the AFM-IR methodology for skeletal tissues and ii) to apply the methodology to sheep cancellous bone with the objective to obtain novel findings on the composition and structure of trabecular packets.To develop the methodology, we assessed spatial and temporal reproducibility using a known homogeneous material (polymethylmethacrylate, PMMA). We verified that the major peak positions were similar and not shifted when compared to traditional Fourier Transform Infrared imaging (FTIRI). When AFM-IR was applied to sheep cancellous bone, the mineral-to-matrix ratio increased and the acid phosphate substitution ratio decreased as a function of tissue maturity. The resolution of the technique enabled visualization of different stages of the bone maturation process, particularly newly-formed osteoid prior to mineralization. We also observed alternating patterns of IR parameters in line and imaging measurements, suggesting the apposition of layers of alternating structure and / or composition that were not visible with traditional spectroscopic methods. In conclusion, nanoscale IR spectroscopy demonstrates novel compositional and structural changes within trabecular packets in cancellous bone. Based on these results, AFM-IR is a valuable tool to investigate cancellous bone at the nanoscale and, more generally, to analyze small dynamic areas that are invisible to traditional spectroscopic methods.

show abstract

“…Bromage et al (2009) show, however, that lamellae are formed following a long period rhythm (analogous to the striae of Retzius in teeth) in Wistar rats, macaques, patas monkeys, sheep and humans. Although this seems contradictory, Wistar rats, and presumably other small mammals, have fast rhythmic growth and a striae of Retzius repeat interval of one day (Bromage et al, 2009(Bromage et al, , 2011. These rhythmic patterns suggest a more or less constant and cyclical rate of bone deposition that is dependent on species.…”

Section: Lamellar Bone Formationmentioning

confidence: 99%

A literature review of the spatial organization of lamellar bone

Mitchell

Heteren

2016

Comptes Rendus Palevol

View full text Add to dashboard Cite

a b s t r a c tIdentification and interpretation of bone tissue types is the primary goal of histological analysis. Lamellar bone, a fundamental tissue, is generally easily identifiable in polarized microscopy. It is important, however, to understand the formation and structure of the tissues that are being studied. Lamellae are widely accepted to form a plywood-like structure, but this hypothesis has been and continues to be contested. Here, we discuss the common interpretations provided by the scientific community as to the spatial organization of lamellar bone. The two major competing hypotheses, lamellae that have alternating tissue compositions versus lamellae that alternate in fiber orientation, are described. In addition, recent research has led to a confounding array of interpretations of lamellae, with several authors viewing the thickness, orientations and composition of lamellae differently. We conclude that a blended approach is needed, as the varying methods are not easily comparable to one another. With an integrated approach, lamellae can be better understood, improving interpretations, including histological ones. Mots clés :Os lamellaire Orientation des fibres de collagène Lamellae hétérogènes r é s u m é L'identification et l'interprétation des types de tissu osseux constituent le but principal de l'analyse histologique. L'os lamellaire, un tissu fondamental, est généralement facilement identifiable au microscope polarisant. Il est cependant important de comprendre la formation et la structure des tissus qui sont étudiés. Il est largement admis que les « lamellae » forment une structure de type contreplaqué, mais cette hypothèse a été et continue à être contestée. Dans cet article sont discutées les interprétations courantes fournies à la communauté scientifique quant à l'organisation spatiale de l'os lamellaire. Les deux hypothèses majeures en présence sont, d'une part, que les lamellae ont des compositions de tissu alternant, d'autre part, qu'elles alternent dans l'orientation des fibres. En outre, une recherche récente a conduit à un ensemble déconcertant d'interprétations des lamellae, avec des auteurs envisageant différemment l'épaisseur, les orientations et la composition des lamellae. Nous en concluons qu'une approche combinée est nécessaire, sachant que les diverses méthodes d'étude ne sont pas facilement comparables les unes aux autres. Avec une approche intégrée, les lamellae peuvent être mieux comprises, en perfectionnant les interprétations incluant celles de type histologique.

show abstract

Enamel-Calibrated Lamellar Bone Reveals Long Period Growth Rate Variability in Humans

Cited by 23 publications

References 16 publications

Rethinking the nature of fibrolamellar bone: an integrative biological revision of sauropod plexiform bone formation

Rethinking the nature of fibrolamellar bone: an integrative biological revision of sauropod plexiform bone formation

Dynamic structure and composition of bone investigated by nanoscale infrared spectroscopy

A literature review of the spatial organization of lamellar bone

Contact Info

Product

Resources

About