Enamel matrix derivative promotes new bone formation in xenograft assisted maxillary anterior ridge preservation—A randomized controlled clinical trial

Mercado, Faustino; Vaquette, Cédryck; Hamlet, Stephen; Ivanovski, Sašo

doi:10.1111/clr.13742

Cited by 13 publications

(80 citation statements)

References 58 publications

(87 reference statements)

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“…A higher amount of newly formed bone at 6 months was also observed in a human RCT investigating the effect of EMD in association with deproteinized bovine bone mineral (DBBM) as compared to DBBM alone for maxillary sinus floor elevation [ 10 ]. The same results were obtained at 4 months in another RCT testing the same biomaterials for ridge preservation after maxillary anterior teeth extraction [ 11 ]. A recent in vitro study [ 12 ] investigated the effect of EMD on human osteoclasts precursors after interaction with activated endothelium, finding a concentration-dependent inhibition of osteoclastogenesis.…”

Section: Introductionsupporting

confidence: 72%

“…Since the effects of amelogenins on cells involved in periodontal regeneration found substantial support in the literature, the hypothesis that EMD could stimulate osteoblast and bone regeneration has been studied both in recently published animal [ 8 , 9 ] and human studies [ 10 , 11 ]. Jung et al [ 9 ] compared the effect of EMD-liquid as an adjunct to biphasic calcium phosphate (BCP) in a rabbit calvarial model, as evaluated through micro-CT and histomorphometric analysis.…”

Section: Introductionmentioning

confidence: 99%

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The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

et al. 2021

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Enamel matrix derivative (EMD) has been successfully used for periodontal regeneration in intrabony defects. Recently, its use for peri-implant bone regeneration has also been hypothesized. The aim of this paper is to review preclinical and clinical studies investigating the use of EMD in correspondence with titanium implants, alone or as an adjunct to other biomaterials. Clinical trials and case series with more than five cases were included. Seven in vitro studies evaluated the effect of EMD, placed on titanium surfaces: An increase in proliferation and viability of osteoblasts was observed in all but two studies. An increase in TGF-β1 and osteocalcin production, alkaline phosphatase activity, and angiogenesis was also reported. Nine animal studies investigated the use of EMD at implant placement or for bone regeneration of peri-implant bone defects, and some of them reported a significant increase in bone formation or bone-to-implant contact. In four of eleven clinical trials on humans, EMD was successfully used at implant placement. The other seven evaluated the use of EMD in protocols for the treatment of peri-implantitis. In conclusion, the results of EMD seem promising, but further randomized clinical trials are needed to evaluate its efficacy.

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Section: Introductionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

et al. 2021

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“…Seven articles were subjected to full-text evaluation, and the reasons listed in Table 1 led to the exclusion of three [22][23][24] of them. As a result, this meta-analysis and systematic review included four human studies [25][26][27][28] .…”

Section: Resultsmentioning

confidence: 99%

“…The follow-up period lasted 4 to 6 months in all included articles. Among the four articles included, one article took deproteinized bovine bone mineral with 10% collagen and EMD and covered with free gingival graft (DBBMC-EMD+FGG) as the test group and DBBMC+FGG as the control group 25 ; one article took DBBMC and EMD and covered with two layers of a resorbable collagen membrane (DBBMC-EMD+RCM) as the test group and DBBMC+RCM as the control group 26 ; one article took DBBMC and EMD and covered with two layers of a native bilayer non-cross-linked resorbable collagen membrane (DBBMC-EMD+NCLM) as the test group and DBBMC+NCLM as the control group 27 ; and another article took alloplastic bone substitute (BoneCeramic [BC]) combined with EMD, and covered with lingual or palatal ap (BC-EMD+LP) as the test group and BC +LP as the control group 28 27 and the other three are medium-risk 25,26,28 . The 3 medium-risk articles were nonblind in the blinding of participants and personnel.…”

Section: Description Of Studiesmentioning

confidence: 99%

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Effect of Enamel Matrix Derivative and bone grafts on Alveolar Ridge Preservation in Bone Healing: A Systematic Review and Meta-Analysis

Huang

et al. 2022

Preprint

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Objectives The purpose of this systematic review and meta-analysis was to compare the effectiveness of using bone grafts alone to alveolar ridge preservation (ARP) using a combination of enamel matrix derivative (EMD) and bone grafts. Materials and Methods Searches were conducted via electronic approaches for articles published up to July 2022. Changes in buccal ridge height (BH), palatal ridge height (PH), ridge width (RW) and the fraction of new bone (%NB), residual graft (%RG), soft tissue matrix (%STM) were extracted from original articles for meta-analysis. ResultsThis review covered four randomized controlled clinical trials. The weighted mean difference (WMD) of BH, PH, RW2 with RW1, and RW2 with RW3 were 0.32mm (95% CI = -0.03~0.67, P = 0.08), 0.00mm (95% CI = -0.23 ~ 0.23, P = 0.99), 0.01 mm (95% CI= -0.20~ 0.21, P = 0.95), and 0.09mm (95% CI = -0.17 ~ 0.35, P = 0.50), respectively. The WMD of %NB, %RG, and %STM were 22.48% (95% CI = 9.24~35.71, P = 0.0009), -5.62% (95% CI = -28.14~16.89, P = 0.62), and -11.90% (95% CI = -19.29~-5.73, P = 0.002), respectively. Conclusion This review revealed that bone healing in sockets under ARP with EMD and bone grafts was better than that with bone grafts alone. There was significant difference in the %NB and %STM. Clinical Relevance When compared to bone grafts alone, the use of EMD with bone grafts during ARP has supernumerary advantages for bone healing.

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Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

Amo¹,

Monje

2022

Journal of Periodontology

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Background: The use of biologics may be indicated for alveolar ridge preservation (ARP) and reconstruction (ARR), and implant site development (ISD). The present systematic review aimed to analyze the effect of autologous bloodderived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor-BB (rhPDGF-BB), and recombinant human bone morphogenetic protein-2 (rhBMP-2), on the outcomes of ARP/ARR and ISD therapy (i.e., alveolar ridge augmentation [ARA] and maxillary sinus floor augmentation [MSFA]). Methods: An electronic search for eligible articles published from January 2000 to October 2021 was conducted. Randomized clinical trials evaluating the efficacy of ABPs, EMD, rhBMP-2, and rhPDGF-BB for ARP/ARR and ISD were included according to pre-established eligibility criteria. Data on linear and volumetric dimensional changes, histomorphometric findings, and a variety of secondary outcomes (i.e., clinical, implant-related, digital imaging, safety, and patientreported outcome measures [PROMs]) were extracted and critically analyzed. Risk of bias assessment of the selected investigations was also conducted. Results: A total of 39 articles were included and analyzed qualitatively. Due to the high level of heterogeneity across studies, quantitative analyses were not feasible. Most studies in the topic of ARP/ARR revealed that the use of biologics rendered similar results compared with conventional protocols. However, when juxtaposed to unassisted healing or socket filling using collagen sponges, the application of biologics did contribute to attenuate post-extraction alveolar ridge atrophy in most investigations. Additionally, histomorphometric outcomes were positively influenced by the application of biologics. The use of biologics in ARA Both authors contributed equally to this study.

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Enamel matrix derivative promotes new bone formation in xenograft assisted maxillary anterior ridge preservation—A randomized controlled clinical trial

Abstract: Article type : Original Research Enamel matrix derivative promotes new bone formation in xenograft assisted maxillary anterior ridge preservation -a randomized controlled clinical trial.

Cited by 13 publications

References 58 publications

The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

Effect of Enamel Matrix Derivative and bone grafts on Alveolar Ridge Preservation in Bone Healing: A Systematic Review and Meta-Analysis

Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

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