Enantiomeric Discrimination by Anisotropic Polarization of Two-Dimensional ReSe₂ with Chiral Au Nanoparticles

Abstract

Enantiomeric discrimination plays a crucial role in the fields of analytical science and chemical biology. Herein, we achieve chiral recognition via angle-resolved polarized Raman scattering using a composite material consisting of an anisotropic twodimensional material, ReSe 2 , and chiral Au nanoparticles (CAuNPs). A near-field effect is induced through the attachment of CAuNPs to ReSe 2 , in conjunction with modulation of polarized light, resulting in simultaneous angular polarization of ReSe 2 . This angular polarization was utilized for the chiral detection of tyrosine. Varying enantiomeric excess (ee) leads to inverse nonreciprocal angular deflections, which we propose arise from interactions between the chiral near-field and optical vectors modified by chiral molecules with distinct ee values. This phenomenon is primarily attributed to the optical spin Hall effect within the field, generating distinct vector deflections that can be utilized to discriminate between different enantiomers. Ultimately, we demonstrate selective identification of chiral substances by establishing a correlation between the optical inversion angle and ee value. This investigation presents an efficient and insightful approach for achieving rapid detection of chiral substances using rational optical devices.