Enantiomeric purity assay of moxifloxacin hydrochloride by capillary electrophoresis

Cruz, Lou Ann; Hall, R T

doi:10.1016/j.jpba.2004.12.004

Cited by 52 publications

(25 citation statements)

References 10 publications

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“…Analysis of the same enantiomers via chiral HPLC was more precise and sensitive and provided lower LOD and LOQ values. A validated method for the resolution of the four stereoisomers of moxifloxacin hydrochloride with highly sulfated g-CD (HS-g-CD) was published by Cruz and Hall [91]. In order to maintain adequate separation, the BGE and instrument parameters needed to be maintained within 1% of the specified value.…”

Section: Sulfur-derivatized Anionic Cdsmentioning

confidence: 99%

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Kahle

Foley

2007

Electrophoresis

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Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKCThe separation of enantiomers using electrokinetic chromatography (EKC) with chiral microemulsions is comprehensively reviewed through December 1, 2006. Aqueous chiral EKC separations based on other pseudostationary phases such as micelles and vesicles or on other chiral selectors such as CDs, crown ethers, glycopeptides, ligand exchange moeities are also reviewed from both mechanistic and applications perspective for the period of

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Section: Sulfur-derivatized Anionic Cdsmentioning

confidence: 99%

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Kahle

Foley

2007

Electrophoresis

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“…A chiral CE method was developed to evaluate whether racemization is a potential degradation pathway for moxifloxacin drug substance or ophthalmic/otic solution [81]. The study demonstrated that racemization into the RRenantiomer or RS-or SR-diastereoisomers is unlikely.…”

Section: Pharmaceutical Applications Of Chiral Ce: Applicationsmentioning

confidence: 99%

Capillary electrophoresis for the analysis of small‐molecule pharmaceuticals

2006

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This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pK(a) of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.

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“…The bactericidal action of Moxi results from trapping of enzymes on DNA and lethal release of doublestranded breaks, thereby inhibiting of cell replication [3]. Various analytical methods have been cited in literature for Moxi determinations including spectrophotometry, spectrofluorimetry, atomic absorption spectrometry, conductometry, voltammetry [4][5][6][7][8][9][10], high performance liquid chromatography-ultraviolet (HPLC-UV), HPLC-fluorescence(HPLC-Fl), capillary electrophoresis(CE), and HPLC-mass spectrometry (HPLC-MS) [4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Determination of Moxifloxacin by ZnO Nanorodes Modified ion Selective Electrode

Idress¹,

Elbashir²,

Nur³

2017

Pharm Anal Acta

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Potentiometric determination of moxifloxacin (Moxi) by ion selective electrode based on ZnO nanorods incorporation with HPβ-CD as sensing ionophore and (KTFPB) potassium tetrakis-(3,5(triflouromethyl) phenyl borate ion as anionic site (additive) in polyvinyl chloride (PVC) membrane, without inner reference solution was developed. The sensor shows nearly nernstian response over a concentration range ( 5 × 10 -8 M to 1 × 10 -2 M) with a slope of 21.9 ± 0.16 mv decade -1 of concentration with a limit of detection (LOD) 0.127 μM. The electrode exhibits a fast dynamic response of 2 s for a period of 6 months without significant change in its characteristics with excellent stability and sensitivity toward inorganic species. The method is accurate and precise as indicated by the mean recoveries 99.5% with RSD less than 2%. The proposed method was successfully applied for the determination of Moxi in pure form and its pharmaceutical formulations.

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Enantiomeric purity assay of moxifloxacin hydrochloride by capillary electrophoresis

Cited by 52 publications

References 10 publications

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Capillary electrophoresis for the analysis of small‐molecule pharmaceuticals

Potentiometric Determination of Moxifloxacin by ZnO Nanorodes Modified ion Selective Electrode

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