Enantiomeric quantification of (S)-(+)-methamphetamine in urine by an immunoaffinity column and liquid chromatography–electrospray-mass spectrometry

Forensic Science

“…A microchip-based liquid-liquid extraction for the GC analysis of urine for amphetamine-type stimulants has been developed (415). A method using an immunoaffinity column and ESI-LC-MS was developed for the quantitation and enantiomeric determination of (S)-(+)-methamphetamine in urine (416). Amphetamine and related compounds were quantified in urine by GC/NPD or GC/ MS. (417).…”

Chromatographic Immunoassays: Strategies and Recent Developments in The Analysis of Drugs and Biological Agents

“…Other applications have utilized the direct detection format in clinical tests for bacteria such as Escherichia coli and methicillin-resistant Staphylococcus aureus [39,40]. This format has also been employed for the analysis of various low mass targets, including drugs, herbicides, toxins and synthetic dyes [7,9,[41][42][43][44][45]. A recent report used chemiluminescent detection to directly measure bovine serum albumin that had been selectively adsorbed to columns packed with molecularly imprinted microspheres [46].…”

“…These applications have utilized detection based on light absorption, fluorescence, chemiluminescence or MS [7,10,[38][39][40][41][42][43][44][45][46][47]. This method has been used for large targets such as proteins, peptides and carbohydrates [7].…”

“…For instance, immmunoextraction has been coupled with LC-MS for the measurement of S-methamphetamine in urine [45]. Immunoextraction columns have been used off-line with ultra-high performance LC (UHPLC) and MS/MS for the determination of aflatoxin M 1 in ice cream [49], and immunoaffinity columns were utilized off-line with LC-MS/MS for the analysis of multiple mycotoxins in food [50,51].…”

Progress in Sample Pretreatment for Analysis of Estrogens with Liquid Chromatography-Mass Spectrometry

“…In order to seek more effective, environmental friendly, and economic enrichment materials for the application of on-line SPE analysis, many scholars pay attention on the development of new materials, including amino column [65] , hydrosulfonyl column [66] , copper isonicotinate coordination polymer [67] , -cyclodextrin silica gel [68] , polymer columns [69,70] , immunoaffinity column [71,72] , expanded graphite [73] , multi-walled carbon nanotube [74] , and some application even use cotton [75] and cigarette filter [76,77] for on-line adsorption of organic pollutants and perfect results could be obtained. The properties of these new adsorbents are low cost, easy producibility, some of which can be used repeatedly.…”