Enantiomeric Resolution and Growth-Retardant Activity in Rice Seedlings of Uniconazole

Sun, Jianqiang; Zhang, Anping; Zhang, Jing; XueMei, Xie; Liu, Weiping

doi:10.1021/jf203742x

Cited by 32 publications

(21 citation statements)

References 20 publications

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“…Studies have shown that the introduction of different functional groups is a strategy used to improve the biological activity. The influence of structures on antifungal activities is useful for guiding synthesis and screening the most promising potent broad spectrum antifungal compounds.…”

Section: Resultsmentioning

confidence: 99%

The enhanced biological activities of three Zn (II) complexes based on different 1,2,4‐triazole fungicides

Ren

Wei

et al. 2018

Applied Organom Chemis

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In order to screen effective fungicides, three Zn (II) complexes, [ZnL14 (NO3)2]·2H2O·2EtOH (1), [ZnL24 (NO3)2] (2), and [ZnL34 (DMF)2](NO3)2 (3), (L1 = paclobutrazol, L2 = diniconazole, and L3 = hexaconazole), were synthesized and characterized by elemental analysis, FT‐IR spectroscopy, and single‐crystal XRD. The antifungal activities of these complexes were then evaluated against four selected fungi using the mycelial growth rate method. The resulting data indicate that all the complexes show the enhanced antifungal activities than the corresponding ligand and mixtures. And, the interactions between the metal salt and ligands in the three complexes seem to be synergistic. According to the study of the influence of the structures on the activity, complex 2 with C=C linkage and 2,4‐dichlorophenyl moieties enhances the bioactivity significantly, especially against Wheat gibberellic (II). Density functional theory (DFT) calculations were carried out to help explain the enhanced bioactivity of the Zn (II) complexes. Meanwhile, all complexes are excellent grow‐regulators, especially complex 3. The resulting data show that the complexes based on triazole fungicides have the potential applications in agriculture.

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Section: Resultsmentioning

confidence: 99%

The enhanced biological activities of three Zn (II) complexes based on different 1,2,4‐triazole fungicides

Ren

Wei

et al. 2018

Applied Organom Chemis

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“…The molecular docking with the highest score was chosen for further analysis. 16,17 3 | RESULTS AND DISCUSSION…”

Section: Separation Mechanisms and Molecular Docking Studiesmentioning

confidence: 99%

Enantioseparation of napropamide by supercritical fluid chromatography: Effects of the chromatographic conditions and separation mechanism

et al. 2018

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Supercritical fluid chromatography (SFC) is already used for enantioseparation in the pharmaceutical industry, but it is rarely used for the separation of chiral pesticides. Comparing with high performence liquid chromatography, SFC uses much more environmnetal friendly and economic mobile phase, supercritical CO . In our work, the enantioseparation of an amide herbicide, napropamide, using three different polysaccharide-type chiral stationary phases (CSPs) in SFC was investigated. By studying the effect of different CSPs, organic modifiers, temperature, back-pressure regulator pressures, and flow rates for the enantioseparation of napropamide, we established a rapid and green method for enantioseparation that takes less than 2 minutes: The column was CEL2, the mobile phase was CO with 20% 2-propanol, and the flow rate was 2.0 mL/min. We found that CEL2 demonstrated the strongest resolution capability. Acetonitrile was favored over alcoholic solvents when the CSP was amylose and 2-propanol was the best choice when using cellulose. When the concentration of the modifiers or the flow rate was decreased, resolutions and analysis times increased concurrently. The temperature and back-pressure regulator pressure exhibited only minor influences on the resolution and analysis time of the napropamide enantioseparations with these chiral columns. The molecular docking analysis provided a deeper insight into the interactions between the enantiomers and the CSPs at the atomic level and partly explained the reason for the different elution orders using the different chiral columns.

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“…Heterocycles bearing a 1,2,4‐triazoles moiety have several applications in organocatalysts, medicines, and pesticides . Moreover, thiazolo[3,2‐b] [1,2,4]triazoles nucleus has been the subject of intense interest because of its remarkable biological properties …”

Section: Introductionmentioning

confidence: 99%

Synthesis of Thiazolo[3,2‐b] [1,2,4]triazoles through Pd‐Catalyzed Copper‐Free Sonogashira Coupling Reaction

2019

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The synthesis of 2-substituted thiazolo [3,2-b] [1,2,4]triazoles is accomplished copper-free, Pd-catalyzed Sonogashira reaction of 6-(iodomethyl)-2-methylthiazolo[3,2-b][1,2,4]triazole with terminal alkynes in DMF at 70°C. The coupling reaction of phenylacetylene and 4-ethynyltoluene gave the desired products in high yields. While, the Sonogashira reaction of alkynes such as 1-hexyne, 1-octyne, propargyl alcohols, and propargyl amines afforded the products in good yields.ChemistrySelect 2019, 4, 9238 -9240

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Enantiomeric Resolution and Growth-Retardant Activity in Rice Seedlings of Uniconazole

Cited by 32 publications

References 20 publications

The enhanced biological activities of three Zn (II) complexes based on different 1,2,4‐triazole fungicides

The enhanced biological activities of three Zn (II) complexes based on different 1,2,4‐triazole fungicides

Enantioseparation of napropamide by supercritical fluid chromatography: Effects of the chromatographic conditions and separation mechanism

Synthesis of Thiazolo[3,2‐b] [1,2,4]triazoles through Pd‐Catalyzed Copper‐Free Sonogashira Coupling Reaction

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