Enantiomeric separation of amino acid derivatives by non‐aqueous capillary electrophoresis using quinine and related compounds as chiral additives

Recent advances in amino acid analysis by capillary electrophoresis

“…Quinine, quinidine, cinchonine, cinchonidine, tertiobutylcarbamoyl quinidine, tertbutylcarbamoylated quinine (TBCQ) and other quinine derivatives were also used as chiral selectors for nonaqueous CE. A separation preference to TBCQ was noticed, and amino acids were used as well as N-protected amino acids [40][41][42].…”

Effects of background electrolyte composition and addition of selectors on separation selectivity in nonaqueous capillary electrophoresis

“…Bjørnsdottir et al [65] used S-(1)or R- (2) camphorsulfonate for the enantioseparation of basic drugs in acetonitrile containing 1 M acetic acid and 0.2 mM Tween 20 which was added to reduce the EOF. Piette et al [66][67][68][69][70] investigated the potential of quinine, quinidine, other cinchona alkaloids and derivatives as chiral counterions for the enantiomeric separation of N-protected amino acids using a mixture of 12.5 mM ammonia and 100 mM octanoic acid in an ethanolmethanol mixture (60:40 v/v). Recently, Czerwenka et al [71] extended the range of application of tert-butylcarbamoylquinine to peptides with up to six amino acid residues.…”