Enantiomeric separation of drugs and herbicides on a β‐cyclodextrin‐bonded stationary phase

Abstract

A chemically bonded beta-cyclodextrin chiral stationary phase for HPLC was prepared in a "one pot" process by the reaction of a phenylated beta-cyclodextrin with silica gel. Various racemic analytes such as drugs (aminoalcohol adrenergic beta-blockers, benzodiazepine anxiolytics, arylpropionic acid antiinflammatory agents) and herbicides (aryloxypropionic acids and esters) were separated on the prepared material. The column showed good chiral recognition ability for most of the solutes tested when using heptane and either 2-propanol or chloroform as organic mobile phase modifiers.

Chemical composition of essential oils from needles, branches and cones of Pinus pinea, P. halepensis, P. pinaster and P. nigra from central ltaly

“…Roussis et al 9 found β-caryophyllene to be the main constituent, but this substance was not found at all by Tazerouti et al 15 or Zafra et al 10 Mirov et al 25 reported α-pinene as the main compound, together with myrcene, in agreement with our findings. Tazerouti et al 15 also found myrcene to be the principal constituent.…”

“…Roussis et al 9 found β-caryophyllene to be the main constituent, but this substance was not found at all by Tazerouti et al 15 or Zafra et al 10 Mirov et al 25 reported α-pinene as the main compound, together with myrcene, in agreement with our findings. Tazerouti et al 15 also found myrcene to be the principal constituent. Zafra et al 10 reported as main constituents sabinene followed by α-pinene for during all the months of the investigation; also, in the essential oil of the twigs, sabinene was the major compound, followed by α-pinene and terpinolene.…”

“…[4][5][6] Some studies on the chemical composition of the essential oils obtained from needles and branches of these Pinus spp. have been published, [7][8][9][10][11][12][13][14][15] but no author has examined oil obtained from the female cones; furthermore, only one paper has compared the oils obtained from leaves of P. pinea, P. halepensis and P. nigra. 9 Chalchat et al 16 correlated the chemical composition and the antimicrobial activity of natural and oxygenated essential oils obtained from P. sylvestris, P. pinaster and other Pinaceae; the oxygenated oils gave the best results.…”

Preparation and chromatographic properties of a multimodal chiral stationary phase based on phenyl‐carbamate‐propyl‐β‐CD for HPLC

“…Some of the solutes were racemic mixtures whereas in others one enantiomer was predominant (see structures in Table 1). The enantiomeric purity of the solutes studied had been checked in previous works by polarimetric detection [8,13].…”

Enantioseparation and Enantioselective Analysis of Chiral Herbicides

“…The mechanism of chiral recognition implies a synergistic interaction of carboxylic acid analyte with the chiral selector and achiral free -aminopropyl units on silica. (Vinkovic et al, 2001) In a study by Badjah-Hadj-Ahmed (Tazerouti et al, 2002), eleven 2-aryloxypropionic acids and esters herbicides were partially separated on the prepared phenylated -CD CSP when using heptane and either IPA or chloroform as organic mobile phase modifier.…”