Enantiopure polythiophene nanoparticles. Chirality dependence of cellular uptake, intracellular distribution and antimicrobial activity

Palamà, Ilaria Elena; Maria, Francesca Di; Zangoli, Mattia; D’Amone, Stefania; Manfredi, Giovanni; Barsotti, Jonathan; Lanzani, Guglielmo; Ortolani, Luca; Salatelli, Elisabetta; Gigli, Giuseppe; Barbarella, Giovanna

doi:10.1039/c9ra04782d

Cited by 16 publications

(8 citation statements)

References 51 publications

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“…E. coli DH5-α have been developed with several mutations to obtain high-efficiency transformation [ 31 ]. Many pores and appendices present in the cellular envelope of DH5-α bacteria could confer the distinctive antibacterial response to the extracts from the other strains [ 32 , 33 ].…”

Section: Results and Decisionmentioning

confidence: 99%

Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of Eupatorium glutinosum Lam. Leaves

et al. 2023

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This research reported a hydrogel loaded with the ethanolic and methanolic extracts of Eupatorium glutinosum Lam. The E. glutinosum extracts were characterized by phytochemical screening, Fourier-transform infrared spectroscopy (FTIR), thin-layer chromatography (TLC), and UV/Vis profile identification. This research also evaluated the pharmacological activity of the extracts using antimicrobial, antioxidant, and anti-inflammatory assays prior to polymeric encapsulation. Results indicate that extracts inhibit the Escherichia colii DH5-α (Gram negative) growth; excellent antioxidant activity was evaluated by the ferric reducing power and total antioxidant activity assays, and extracts showed an anti-hemolytic effect. Moreover, the cotton and microcrystalline cellulose hydrogels demonstrate successful encapsulation based on characterization and kinetics studies such as FTIR, extract release, and swelling degree. Moreover, effective antibacterial activity was registered by the loaded hydrogel. The overall results encourage and show that Eupatorium glutinosum-loaded hydrogel may find a wide range of bandage and wound healing applications in the biomedical area.

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Section: Results and Decisionmentioning

confidence: 99%

Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of Eupatorium glutinosum Lam. Leaves

et al. 2023

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“…The residual organic solvent can be removed by evaporation under reduced pressure or by dialyzing the colloidal suspension 35 . Chart 1 reports the chemical structures of different PTs that have been reported to form NPs following this methodology 37–49 …”

Section: Synthesis Of Semiconducting Pt‐npsmentioning

confidence: 99%

“…It has also been reported that it is possible to prepare chiral PT‐NPs by functionalizing the side chains of polymers with enantiopure R or S chiral moieties 45 . Chiral nanoobjects may interact differently with chiral biomolecules and affect physiological events 101 .…”

Section: Biological Applications Of Pt‐npsmentioning

confidence: 99%

Synthesis, characterization, and biological applications of semiconducting polythiophene‐based nanoparticles

Zangoli

Maria

2020

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In recent years, polythiophene‐based nanoparticles (PT‐NPs) have attracted increasing attention because of their outstanding characteristics deriving from a wealth of properties such as charge conduction in the oxidized/reduced states, light absorption/emission at an appropriate wavelength, geometrical adaptability, thermal and chemical stability, and solubility in common solvents. Furthermore, the great synthetic flexibility of the thiophene core has allowed the engineering of a multitude of nanomaterials with made‐to‐order properties. This review is focused on the synthesis and characterization of aqueous PT‐NPs and their biological applications. In particular, both in vitro and in vivo bioapplications will be presented, in which thiophene‐based nanomaterials act as photoactuators, that is, as exogenous components capable of transforming a primary stimulus of light into a highly spatiotemporally resolved secondary stimulus able to alter cell's physiological functions. Furthermore, examples of applications of PT‐NPs in biomedicine, such as photodynamic therapy and photothermal therapy, will be discussed.

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“…Because the direct self-assembly approach does not alter the chemical structures of CPs, it preserves the best properties of CPs as originally designed. Water-dispersible P3HT NPs have been extensively explored through two different methods, namely nanoprecipitation ( Fraleoni-Morgera et al., 2004 ; Palamà et al., 2019 ; Shimizu et al., 2008 ; Zangoli et al., 2017 ; Zucchetti et al., 2017 ) and microemulsion ( Nagarjuna et al., 2012 ). In nanoprecipitation, P3HT dissolved in a good solvent like tetrahydrofuran (THF) is slowly added to water as a non-solvent for P3HT.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of water-dispersible poly(3-hexylthiophene) nanoparticles with high yield and excellent colloidal stability

et al. 2022

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Enantiopure polythiophene nanoparticles. Chirality dependence of cellular uptake, intracellular distribution and antimicrobial activity

Abstract: The use of intrinsic chiral molecules opens the door to bio-imaging specific tools and to the development of target-therapy.

Cited by 16 publications

References 51 publications

Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of Eupatorium glutinosum Lam. Leaves

Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of Eupatorium glutinosum Lam. Leaves

Synthesis, characterization, and biological applications of semiconducting polythiophene‐based nanoparticles

Facile synthesis of water-dispersible poly(3-hexylthiophene) nanoparticles with high yield and excellent colloidal stability

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