Enantioselective addition of diethylzinc to aldehydes using 2-azanorbornylmethanols and 2-azanorbornylmethanethiol as a catalyst

(R)-N-[(R)-1-(2-Hydroxy-5-methylphenyl)-2-phenylethyl]-2-methyl-1-phenylpropylammonium chloride

“…The synthesis of enantiopure amine alcohols with a variety of functionalities is an important subject of research because this class of compounds are widespread in natural products, show pharmacological activity and have recently found application in asymmetric synthesis as chiral bases, auxiliaries and ligands (Cimarelli et al, 2002). Chiral aminophenols, which are similar to amino alcohols, are important building blocks in organic synthesis, and have attracted increasing attention in recent years owing to their effect in asymmetric synthesis and asymmetric induction (Cimarelli et al, 2001;Palmieri, 1999Xu et al, 2002;Berrisford et al, 1995;Cimarelli & Palmieri, 1998Hayase et al, 1997;Juaristi et al, 1998;Kitamura et al, 1986Kitamura et al, , 1989Nakano et al, 1997;Rijnberg et al, 1997;Soai et al, 1992;Sola et al, 1998;Watanabe et al, 1991).…”

4-Chloro-2-((1R)-1-{[(R)-(2-chlorophenyl)(cyclopentyl)methyl]amino}ethyl)phenol

“…For general background, see: Ager et al (1996); Berrisford et al (1995); Cimarelli & Palmieri (1998); Cimarelli et al (2001Cimarelli et al ( , 2002; Hayase et al (1997); Nakano et al (1997); Palmieri (1999Palmieri ( , 2000; Soai & Niwa (1992); Watanabe et al (1991); Xu & Pu (2004); Yang et al (2005).…”

“…The X-ray data were collected at Shandong Normal University, China. similar to aminoalcohols, are important building blocks in organic synthesis, and have attracted increasing attention in recent years owing to their effects in asymmetric synthesis and asymmetric induction (Cimarelli et al,2001;Palmieri, 1999Palmieri, , 2000Xu & Pu, 2004;Berrisford et al, 1995;Cimarelli & Palmieri, 1998;Hayase et al, 1997;Nakano et al,1997;Soai et al, 1992;Watanabe et al, 1991).…”

N-[(R)-1-(2-Hydroxy-3,5-dimethylphenyl)ethyl]-N-[(R)-2-methyl-1-phenylpropyl]ammonium chloride

“…The synthesis of enantiopure amino alcohols which have different functionalities is an important subject of research because these compounds are widespread in natural products, show pharmacological activity, and have recently found application in asymmetric synthesis as chiral bases, auxiliaries and ligands (Cimarelli et al, 2002). Chiral amino phenols, which are similar to amino alcohols, are important building blocks in organic synthesis and have attracted increasing attention in recent years, owing to their effect in asymmetric synthesis and asymmetric induction (Palmieri, 1999(Palmieri, , 2000Cimarelli & Palmieri, 1998, 2000Cimarelli et al, 2001;Berrisford et al, 1995;Soai & Niwa, 1992;Kitamura et al, 1989;Juaristi et al, 1998;Rijnberg et al, 1997;Nakano et al, 1997;Watanabe et al, 1991;Kitamura et al, 1986;Hayase et al, 1997;Sola et al, 1998;Xu et al, 2002).…”