Enantioselective Alkylation of Reissert Compounds in Phase Transfer Catalyzed Reactions.

Abstract

Enantioselective syntheses O 0031Enantioselective Alkylation of Reissert Compounds in Phase Transfer Catalyzed Reactions. -The first enantioselective alkylation of isoquinoline Reissert compounds (I) under phase-transfer reaction conditions uses chiral quaternary ammonium salts derived from Cinchona alkaloids as catalysts. Enantioselectivities up to 65% e.e. are achieved. -(BROZDA, D.; HOFFMAN, K.; ROZWADOWSKA*, M. D.; Heterocycles 67 (2006) 1, 119-122; Fac. Chem., Adam Mickiewicz Univ., PL-60-780 Poznan, Pol.; Eng.) -R. Langenstrassen 21-034