Enantioselective allylic substitution catalyzed by Pd0–ferrocenylphosphine complexes in [bmim][PF6] ionic liquid

The chemical industry is under considerable pressure to replace many of the volatile organic compounds (VOCs) that are currently used as solvents in organic synthesis. The toxic and/or hazardous properties of many solvents, notably chlorinated hydrocarbons, combined with serious environmental issues, such as atmospheric emissions and contamination of aqueous effluents is making their use prohibitive. This is an important driving force in the quest for novel reaction media. Curzons and coworkers, for example, recently noted that rigorous management of solvent use is likely to result in the greatest improvement towards greener processes for the manufacture of pharmaceutical intermediates. The current emphasis on novel reaction media is also motivated by the need for efficient methods for recycling homogeneous catalysts. The key to waste minimisation in chemicals manufacture is the widespread substitution of classical 'stoichiometric' syntheses by atom efficient, catalytic alternatives. In the context of homogeneous catalysis, efficient recycling of the catalyst is a conditio sine qua non for economically and environmentally attractive processes. Motivated by one or both of the above issues much attention has been devoted to homogeneous catalysis in aqueous biphasic and fluorous biphasic systems as well as in supercritical carbon dioxide. Similarly, the use of ionic liquids as novel reaction media may offer a convenient solution to both the solvent emission and the catalyst recycling problem.

show abstract

“…64 The product was obtained in moderate enantioselectivity (62-74% ee), which was higher than that observed in conventional solvents.…”

Section: Palladium-catalysed Allylic Substitutionmentioning

confidence: 77%

Untitled

2001

View full text Add to dashboard Cite

show abstract

“…Butadiene telomerization [34], olefin metathesis [110], carbonylation [111], allylic alkylation [112] and substitution [113], and Trost-Tsuji-coupling [114] are other examples of high value for synthetic chemists. …”

Section: Discussionmentioning

confidence: 99%

Organic Synthesis

Earle

Forestièr²,

Olivier‐Bourbigou

et al. 2002

Ionic Liquids in Synthesis

View full text Add to dashboard Cite

“…Enantioselective [48]. A comparison between ILs and THF as solvent showed significantly higher enantioselectivity in ILs for both catalysts, and (R,S)-BPPFDEA gave better results than (S,R)-BPPFA.…”

Section: Asymmetric Allylic Substitutionmentioning

confidence: 96%

Asymmetric Catalysis in Ionic Liquids

Malhotra¹,

Kumar²,

Parmar³

2007

COS

View full text Add to dashboard Cite

Ionic Liquids are becoming increasingly attractive as alternative media for organic synthesis. Strategies such as the use of biocatalysts, chiral ionic liquids, chiral reagent and/or catalysts, have been employed to achieve asymmetric transformations in ionic liquids. The focus of this review is on the developments made in asymmetric catalysis using organometallic and organocatalysts in ionic liquids.

show abstract

Enantioselective allylic substitution catalyzed by Pd0–ferrocenylphosphine complexes in [bmim][PF6] ionic liquid

Cited by 70 publications

References 23 publications

Untitled

Untitled

Organic Synthesis

Asymmetric Catalysis in Ionic Liquids

Contact Info

Product

Resources

About