Enantioselective analysis of Moxifloxacin hydrochloride enantiomers with graphene-β-Cyclodextrin-nanocomposite modified carbon paste electrode using adsorptive stripping differential pulse Voltammetry

Upadhyay, Sharad S.; Kalambate, Pramod K.; Srivastava, Ashwini K.

doi:10.1016/j.electacta.2017.07.141

Cited by 46 publications

(22 citation statements)

References 57 publications

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“…In recent years, β-CD has been recognized as a chiral selector and employed as the chiral element in electrochemical-based sensors. A variety of stereoisomer molecules, including tryptophan [181][182][183][184], phenylalanine [65,185], dihydroxyphenylalanine (DOPA) [186,187], cystine [188], moxifloxacin hydrochloride [189], and clopidogrel [46] have been detected with the β-CD, showing a high preference for one of the enantiomers.…”

Section: Enantioselective Cyclodextrin-based Electrochemical Sensorsmentioning

confidence: 99%

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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Supramolecular chemistry, although focused mainly on noncovalent intermolecular and intramolecular interactions, which are considerably weaker than covalent interactions, can be employed to fabricate sensors with a remarkable affinity for a target analyte. In this review the development of cyclodextrin-based electrochemical sensors is described and discussed. Following a short introduction to the general properties of cyclodextrins and their ability to form inclusion complexes, the cyclodextrin-based sensors are introduced. This includes the combination of cyclodextrins with reduced graphene oxide, carbon nanotubes, conducting polymers, enzymes and aptamers, and electropolymerized cyclodextrin films. The applications of these materials as chiral recognition agents and biosensors and in the electrochemical detection of environmental contaminants, biomolecules and amino acids, drugs and flavonoids are reviewed and compared. Based on the papers reviewed, it is clear that cyclodextrins are promising molecular recognition agents in the creation of electrochemical sensors, chiral sensors, and biosensors. Moreover, they have been combined with a host of materials to enhance the detection of the target analytes. Nevertheless, challenges remain, including the development of more robust methods for the integration of cyclodextrins into the sensing unit.

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Section: Enantioselective Cyclodextrin-based Electrochemical Sensorsmentioning

confidence: 99%

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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“…The resulting electrode could recognize tryptophan enantiomers. [ 86 ] Other chiral hybrids exploited following the similar idea are RGO/ β ‐CD/CPE (carbon paste electrode) for electrochemically sensing moxifloxacin hydrochloride enantiomers; [ 97 ] RGO/ β ‐CD/MB/GCE (MB, methylene blue) for electrochemically sensing chiral carboxylic acids; [ 98 ] RGO/ β ‐CD for electrically and optically sensing tryptophan enantiomers; [ 87 ] RGO/PNP/ β ‐CD/CPE (PNP, platinum nanoparticles) for electrochemically sensing chiral clopidogrels; [ 99 ] RGO/PTCA/ β ‐CD (PTCA, 3,4,9,10‐perylene tetracarboxylic acid) for electrochemically recognizing chiral phenylalanine; [ 100 ] RGO/ferrocene/ β ‐CD for electrochemically recognizing phenylalanine racemate. [ 101 ] These studies evidently show the importance of electrochemical sensors for enantio‐differentiating chiral compounds, due to their merits particularly in easy and fast operation.…”

Section: Construction Of Chiral Graphene Hybrid Materialsmentioning

confidence: 99%

“…The chirality for creating graphene‐based chiral detectors can be derived from amino acids [ 42,54,60 ] and cyclodextrins. [ 82–86,97,98,105–107 ] Kwak and co‐workers took l ‐phenylalanine as chiral source and synthesized a chiral‐functionalized pyrene material (Boc‐ l ‐Phe‐Pyrene). It was utilized as UV–vis and fluorescent probes for enantioselective sensing.…”

Section: Chiral Applications Of Chiral Graphene Hybrid Materialsmentioning

confidence: 99%

“…This distinctive property also makes cyclodextrins appealing for chiral applications. Up to date, α ‐CD, [ 83 ] β ‐CD, [ 84–86,97,98,100,101,105–107 ] and γ ‐CD [ 108 ] have been intensively employed for chiral functionalization of graphene and its derivatives. Among the three types of cyclodextrins, β ‐CD shows the most extensive applicability as its cavity is well matched with common small chiral molecules.…”

Section: Chiral Applications Of Chiral Graphene Hybrid Materialsmentioning

confidence: 99%

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Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

et al. 2021

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Chirality has become an important research subject. The research areas associated with chirality are under substantial development. Meanwhile, graphene is a rapidly growing star material and has hard‐wired into diverse disciplines. Rational combination of graphene and chirality undoubtedly creates unprecedented functional materials and may also lead to great findings. This hypothesis has been clearly justified by the sizable number of studies. Unfortunately, there has not been any previous review paper summarizing the scattered studies and advancements on this topic so far. This overview paper attempts to review the progress made in chiral materials developed from graphene and their derivatives, with the hope of providing a systemic knowledge about the construction of chiral graphenes and chiral applications thereof. Recently emerging directions, existing challenges, and future perspectives are also presented. It is hoped this paper will arouse more interest and promote further faster progress in these significant research areas.

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“…Screen printed electrode (SPE) are low cost and disposable electrodes, but it is difficult to use for molecular recognition after the chiral selector modification because of the poor electrical conductivity of the printed ink. In the past decade, the growing interest in graphene chemistry provided many graphene based fascinating composites for electrochemical sensor fabrication due to their excellent electrical and morphological properties [5,6,7,8]. The preparation of reusable graphene electrodes is an important topic in electrochemical sensing.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Enantiomer Recognition Based on sp3-to-sp2 Converted Regenerative Graphene/Diamond Electrode

et al. 2018

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It is of great significance to distinguish enantiomers due to their different, even completely opposite biological, physiological and pharmacological activities compared to those with different stereochemistry. A sp3-to-sp2 converted highly stable and regenerative graphene/diamond electrode (G/D) was proposed as an enantiomer recognition platform after a simple β-cyclodextrin (β-CD) drop casting process. The proposed enantiomer recognition sensor has been successfully used for d and l-phenylalanine recognition. In addition, the G/D electrode can be simply regenerated by half-minute sonication due to the strong interfacial bonding between graphene and diamond. Therefore, the proposed G/D electrode showed significant potential as a reusable sensing platform for enantiomer recognition.

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Enantioselective analysis of Moxifloxacin hydrochloride enantiomers with graphene-β-Cyclodextrin-nanocomposite modified carbon paste electrode using adsorptive stripping differential pulse Voltammetry

Cited by 46 publications

References 57 publications

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

Electrochemical Enantiomer Recognition Based on sp3-to-sp2 Converted Regenerative Graphene/Diamond Electrode

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