Enantioselective catalytic remote perfluoroalkylation of α-branched enals driven by light

Balletti, Matteo; Wachsmuth, Tommy; Sabato, Antonio Di; Hartley, W. G.; Melchiorre, Paolo

doi:10.1039/d3sc01347b

Cited by 11 publications

(2 citation statements)

References 47 publications

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“…In this context, Melchiorre and co-workers have developed fluorinated organocatalysts that have been successfully applied in enantioselective photoreactions. 162,163 The combination of ion-pairing with chiral organocatalysts was achieved by the List group (cat. in Scheme 3A).…”

Section: Organo-photocatalysismentioning

confidence: 99%

Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop

Beil,

Bonnet,

Casadevall

et al. 2024

JACS Au

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Photocatalysis is a versatile and rapidly developing field with applications spanning artificial photosynthesis, photo-biocatalysis, photoredox catalysis in solution or supramolecular structures, utilization of abundant metals and organocatalysts, sustainable synthesis, and plastic degradation. In this Perspective, we summarize conclusions from an interdisciplinary workshop of young principal investigators held at the Lorentz Center in Leiden in March 2023. We explore how diverse fields within photocatalysis can benefit from one another. We delve into the intricate interplay between these subdisciplines, by highlighting the unique challenges and opportunities presented by each field and how a multidisciplinary approach can drive innovation and lead to sustainable solutions for the future. Advanced collaboration and knowledge exchange across these domains can further enhance the potential of photocatalysis. Artificial photosynthesis has become a promising technology for solar fuel generation, for instance, via water splitting or CO2 reduction, while photocatalysis has revolutionized the way we think about assembling molecular building blocks. Merging such powerful disciplines may give rise to efficient and sustainable protocols across different technologies. While photocatalysis has matured and can be applied in industrial processes, a deeper understanding of complex mechanisms is of great importance to improve reaction quantum yields and to sustain continuous development. Photocatalysis is in the perfect position to play an important role in the synthesis, deconstruction, and reuse of molecules and materials impacting a sustainable future. To exploit the full potential of photocatalysis, a fundamental understanding of underlying processes within different subfields is necessary to close the cycle of use and reuse most efficiently. Following the initial interactions at the Lorentz Center Workshop in 2023, we aim to stimulate discussions and interdisciplinary approaches to tackle these challenges in diverse future teams.

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Section: Organo-photocatalysismentioning

confidence: 99%

Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop

Beil,

Bonnet,

Casadevall

et al. 2024

JACS Au

View full text Add to dashboard Cite

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“…21 Harnessing the addition process of the electrophilic radical to the dienamine intermediate, the same group further developed other γ-functionalizations of enals recently. 25…”

Section: Aminesmentioning

confidence: 99%

Nucleophilic organocatalysis involving radical intermediates

Yang

2023

Org. Chem. Front.

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Recent Advances in the Enantioselective Construction of gem‐Difluorinated Carbonyl Moieties

Li,

Song

2024

Adv Synth Catal

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The enantioselective introduction of gem‐difluorinated carbonyl (i. e. α,α‐difluoro carbonyl) moieties into organic structures is a synthetically valuable but highly challenging approach. During the past decades, continuous efforts have been made for the developments of synthetic strategies for constructing C(sp3)–CF2R chiral centers with high levels of enantioselectivities. This review summarizes and discusses the recent advance in the enantioselective construction of gem‐difluorinated carbonyl moieties, which are organized according to the reaction categories.

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Enantioselective catalytic remote perfluoroalkylation of α-branched enals driven by light

Abstract: Herein, we report a photochemical organocatalytic method for the asymmetric introduction of perfluoroalkyl fragments (including the valuable trifluoromethyl moiety) at the remote γ-position of α-branched enals. The chemistry exploits the...

Cited by 11 publications

References 47 publications

Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop

Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop

Nucleophilic organocatalysis involving radical intermediates

Recent Advances in the Enantioselective Construction of gem‐Difluorinated Carbonyl Moieties

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