Enantioselective determination of metconazole in multi matrices by high-performance liquid chromatography

He, Ronghai; Fan, Jun; Tan, Qi; Lai, Yecai; Chen, Xiao; Wang, Tai; Jiang, Ying; Yao-mou, Zhang; Zhang, Weiguang

doi:10.1016/j.talanta.2017.09.045

Cited by 36 publications

(15 citation statements)

References 25 publications

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“…Triazole fungicides are particularly important in this context because of their regulatory function, which may interfere with the growth of plants and may result in stunted plant growth, which may even decrease crop yield. Metconazole, a mixture of two pairs of enantiomers and two pairs of diastereomers, is commonly used as a fungicide. The different stereoisomers exhibited different effects on plant growth; therefore, it is a good model to investigate the adverse effects of triazole fungicide application on crop growth.…”

Section: Resultsmentioning

confidence: 99%

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Stereoselective Physiological Effects of Metconazole on Seed Germination and Seedling Growth of Wheat

Deng

Liu

et al. 2020

J. Agric. Food Chem.

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In addition to their fungicidal activity, many triazole fungicides function as plant regulators, which might impose adverse effects on the growth and development of crops. For chiral triazole fungicides, these effects can be alleviated by applying stereoisomers with high fungicidal and low regulator activities. This study investigated the stereoselectivity of four stereoisomers and the racemate of metconazole (2.5 g/100 kg seeds) on emergence and growth of seedlings (BBCH 01-14) in wheat. Wheat seedlings, coated with cis-1S,5R-metconazole, had a significantly lower seedling emergence ratio and shoot length than other metconazole treatments; however, the opposite effects were observed in the trans-1S,5S-metconazole treatment. With regard to the hormonal level, enzyme activity, and gene transcription of gibberellin (GA) and jasmonic acid (JA), cis-1S,5R-metconazole treatment inhibited GA biosynthesis while trans-1S,5S-metconazole treatment promoted GA biosynthesis. Moreover, cis-1S,5R-metconazole, trans-1S,5Smetconazole, trans-1R,5R-metconazole, and racemate treatments increased JA biosynthesis. The oxidative stress responses in trans-1R,5R-metconazole and racemate treatments were more intensive. Therefore, compared with the control, treatment with cis-1R,5Smetcoanzole exhibited minimal influence on wheat seedling growth. The results showed that the application of pure cis-1R,5Smetcoanzole (instead of the racemate) in agricultural management could decrease the risks associated with crop growth and developmental damage.

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Section: Resultsmentioning

confidence: 99%

“…Metconazole is a broad-spectrum triazole fungicide with a plant growth regulator effect 10 that was introduced by the Kureha Corporation in 1992. 11 Based on previous research, cismetconazole exhibited significantly higher antibacterial activity than trans-metconazole.…”

Section: ■ Introductionmentioning

confidence: 99%

Stereoselective Physiological Effects of Metconazole on Seed Germination and Seedling Growth of Wheat

Deng

Liu

et al. 2020

J. Agric. Food Chem.

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“…In recent years, various methods of analysis, including high-performance liquid chromatography (He et al, 2017), ultra-high-performance liquid chromatography tandem mass spectrometry (Arthur et al, 2015), vortex-assisted liquid-liquid microextraction gas chromatography-tandem mass spectrometry (GC-MS/ MS) (Machado et al, 2019), and liquid chromatography-tandem quadrupole mass spectrometry (Barganska et al, 2018), have been reported for the measurement of MEZ in soil, flour, pollens, urine, honey and honeybee. GC-MS/MS is a powerful technique for determining pesticide residues because of its robustness, outstanding sensitivity and selectivity (Hernandez et al, 2013).…”

Section: Sampling Proceduresmentioning

confidence: 99%

Dissipation, residues analysis and risk assessment of metconazole in grapes under field conditions using gas chromatography–tandem mass spectrometry

Guo

Chen

Jiao

et al. 2021

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Metconazole (MEZ) is widely used in prevention and control of fruit and vegetable diseases. Here, a simple and reliable gas chromatography–tandem mass spectrometry (GC-MS/MS) method, using modified QuEChERS (“quick, easy, cheap, effective, rugged and safe”) extraction method, was developed for determining the dissipation and residue of MEZ in grapes and soil, and the dietary risk of MEZ residues in grapes was evaluated for Chinese people. The average recoveries of MEZ in two matrices were 80.72–100.36% with relative standard deviations of 1.56–6.16%. The same limits of detection and quantification in grapes and soil were 0.0006 mg/kg and 0.002 mg/kg, respectively. Under field conditions, the half-life of MEZ dissipation in grapes ranged from 11.75 to 20.39 days. The final residues of MEZ in grapes and soil ranged from 0.002 mg/kg to 0.19 mg/kg at pre-harvest intervals of 7, 14 and 21 days. The whole dietary risk assessment indicated acute hazard index and hazard quotient to be less than 1, implying the risk of MEZ was acceptable. This is the first study conducted on the dissipation, residue analysis and risk assessment of MEZ in grapes, thus providing reference for the detection and risk assessment of MEZ in other agricultural products.

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“…The method was validated and applied to the analysis of the four compounds in flour. While the proposed method was carefully optimized studying the effect of various parameters on the compounds separation, the real sample was spiked and there was no finding of the transformation of the enantiomers/diastereoisomers [47].…”

Section: Some Selected Applications To Enantiomers Separation In Fmentioning

confidence: 99%

Analysis of Enantiomers in Products of Food Interest

et al. 2019

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The separation of enantiomers has been started in the past and continues to be a topic of great interest in various fields of research, mainly because these compounds could be involved in biological processes such as, for example, those related to human health. Great attention has been devoted to studies for the analysis of enantiomers present in food products in order to assess authenticity and safety. The separation of these compounds can be carried out utilizing analytical techniques such as gas chromatography, high-performance liquid chromatography, supercritical fluid chromatography, and other methods. The separation is performed mainly employing chromatographic columns containing particles modified with chiral selectors (CS). Among the CS used, modified polysaccharides, glycopeptide antibiotics, and cyclodextrins are currently applied.

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Enantioselective determination of metconazole in multi matrices by high-performance liquid chromatography

Cited by 36 publications

References 25 publications

Stereoselective Physiological Effects of Metconazole on Seed Germination and Seedling Growth of Wheat

Stereoselective Physiological Effects of Metconazole on Seed Germination and Seedling Growth of Wheat

Dissipation, residues analysis and risk assessment of metconazole in grapes under field conditions using gas chromatography–tandem mass spectrometry

Analysis of Enantiomers in Products of Food Interest

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