Enantioselective determination of (R)- and (S)-sotalol in human plasma by on-line coupling of a restricted-access material precolumn to a cellobiohydrolase I-based chiral stationary phase

Cobalt‐Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides

“…Until now, the enantioseparation of β‐blockers have been achieved in many separation techniques, including gas chromatography 4, liquid chromatography 5–12, thin‐layer chromatography 13–16, supercritical fluid chromatography 17, capillary electrochromatography 18–20 and capillary electrophoresis (CE) 21–27. Among all these separation techniques, CE is an electrodriven separation technique, which has several benefits for the stereoselective analysis.…”

Characterization of carbon nanotubes decorated with NiFe2O4 magnetic nanoparticles as a novel electrochemical sensor: Application for highly selective determination of sotalol using voltammetry

“…Sotalol has two ionizable functionalities, the sulfonamide (pK 8.3) and the amino group (pK 9.8). Sotalol exists to a larger extent in its zwitterion form with a decreased polarity at higher pH values [40]. Sotalol has positive net charge in acidic condition (pH b 7.0) and negative net charge in alkaline condition (pH > 7.0).…”

“…To date, numerous methods have been proposed for the analysis of sotalol using different analytical techniques such as liquid extraction material [39,40], fluorescence [41], high performance liquid chromatographic-electrospray ionization mass spectrometric [42], high performance liquid chromatography-UV detection [43][44][45][46][47][48][49][50], and voltammetry [37,51]. The subtle electronic behavior of nanotubes shows that they are able to mediate electron transfer reactions of electroactive species in solution when they are used as a material to modify electrodes.…”

Optimization Strategy for Purification of a Peptide from Complex Mixtures by Reversed‐Phase Liquid Chromatography with a Back‐Flushing Technique

“…In most cases, the backflushing technique is used to clean or preconcentrate the sample on-line through column switching, in order to increase sensitivity. [17,18] When it is used for purification of a peptide, the sample was injected to the inlet of the column; once the objective component was collected, the mobile phase was pumped from the outlet by turning the valve. This operation allows all compounds to disappear along the column rapidly.…”