2012
DOI: 10.1002/chir.21995
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Enantioselective disposition of omeprazole, pantoprazole, and lansoprazole in a same Brazilian subjects group

Abstract: This work reports the result of the enantioselective disposition of pantoprazole, omeprazole, and lansoprazole in a same group of Brazilian health subjects. Ten nongenotyped healthy subjects were used for this study. Each subject received a single oral dose of 80 mg of pantoprazole, 40 mg of omeprazole, and 30 mg of lansoprazole, and the plasma concentrations of the enantiomers were measured for 8 h postdose. For pantoprazole and omeprazole, among the 10 volunteers investigated, only one volunteer (Subject # 4… Show more

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Cited by 9 publications
(11 citation statements)
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“…2. The two enantiomers of PPIs have been known to show enantioselective disposition in our body [19]. In this instance, the exact determination of the enantiomeric composition of PPIs is very important.…”
Section: Resultsmentioning
confidence: 99%
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“…2. The two enantiomers of PPIs have been known to show enantioselective disposition in our body [19]. In this instance, the exact determination of the enantiomeric composition of PPIs is very important.…”
Section: Resultsmentioning
confidence: 99%
“…The chromatographic data for CSP 1 and CSP 2 are quoted from Ref. [19]. For the chromatographic condition on CSP 3 and CSP 4, see the footnote to Table 1.…”
Section: Resultsmentioning
confidence: 99%
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“…The most frequently used CSPs are polysaccharide-based (amylose and cellulose derivatives). Several research groups contributed to the enantioseparation of PPIs using this type of CSP with remarkable results obtained in developing analytical (Cirilli et al [71][72][73][74][75][76][77]) and bioanalytical (Tanaka et al [48][49][50][51][52], Katsuki et al [54][55][56][57], Cass et al [58][59][60][61][62][63][64][65][66][67][68]) methods and performing pharmacokinetic studies A variety of structurally different cellulose-and amylosederivative CSPs were employed in the analysis of PPIs. Amylose tris(3,5-dimethylphenylcarbamate) was the most frequently used chiral selector, applied in the analysis of all PPIs as well as some of their specific impurities and metabolites, from pharmaceutical, biological and environmental samples.…”
Section: Discussionmentioning
confidence: 99%