Enantioselective hydrolysis of (R/S)-Naproxen methyl ester with sol–gel encapculated lipase in presence of calix[n]arene derivatives

Şahin, Özlem; Erdemir, Serkan; Uyanik, Arzu

doi:10.1016/j.apcata.2009.08.030

Cited by 38 publications

(22 citation statements)

References 47 publications

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“…Sahin and coworkers encapsulated lipase in a support material prepared by the sol-gel process involving polycondensation of TEOS and octyltriethoxysilane with or without calix(n)arene, calix(n)-NH 2 , calix(n)-COOH (n = 4, 6, and 8) and sporopollenin compounds as additives. 79 The results indicated that the calix(4,6)-NH 2 , calix(6)-COOH, and sporopollenin-based encapsulated lipases had particularly higher conversions and enantioselectivities when compared to the unencapsulated lipases.…”

Section: Methods Used For Binding Enzymes While Constructing Nanomatementioning

confidence: 74%

Nanomaterial‐Based Biocatalyst

Lee

et al. 2013

Nanocatalysis Synthesis and Applications

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Section: Methods Used For Binding Enzymes While Constructing Nanomatementioning

confidence: 74%

Nanomaterial‐Based Biocatalyst

Lee

et al. 2013

Nanocatalysis Synthesis and Applications

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“…Bovine serum albumin was used as the standard. The catalytic and specific activities of the sol-gel encapsulated lipases, as well as the effect of the temperature on these parameters, were measured using previously reported methods [1,20]. All of the measurements were performed in triplicate, with the final result being reported as an average of the three measurements.…”

Section: Sol-gel Encapsulation Of Lipasementioning

confidence: 99%

“…The anti-inflammatory activity of the S-form of Naproxen is 28-fold greater than that of the Rform [1]. For this reason, only the S-form of Naproxen is used as a drug for humans, and significant research efforts have been focused on the production of the S-form of Naproxen as a single enantiomer.…”

Section: Introductionmentioning

confidence: 98%

Enantioselective hydrolysis of (R,S)-Naproxen methyl ester using Candida rugosa lipase with calix[4]arene derivatives

Akceylan

Akoz

Şahin

2014

J Incl Phenom Macrocycl Chem

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Candida rugosa lipase has been immobilized on a variety of calix[4]arene derivatives using the sol-gel encapsulation technique, and the catalytic activities of the resulting encapsulated lipases towards the hydrolysis of pnitrophenyl palmitate and the hydrolytic kinetic resolution of racemic Naproxen methyl ester were evaluated using standard techniques. The results revealed that the calix[4]-arene-based immobilized encapsulated lipases 5-CRL and 6-CRL gave higher levels of enantioselectivity and conversion than the free encapsulated lipase.

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“…With classes of macrocyclic compounds used as host receptors are focused on cyclodextrin [7,8] and calix[n]arenes [9,10]. Initially, natural and substitutional a, b, c-cyclodextrins were served to encapsulate the drugs into their hydrophobic cavities, hoping to improve the biological utility of the drugs.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic studies on the inclusion interaction of p-sulfonatocalix[6]arene with vitamin B6

Song

Chao

et al. 2011

J Incl Phenom Macrocycl Chem

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The formation of the inclusion complex of p-sulfonatocalix[6]arene (SCX6) with different forms of vitamin B 6 (VB 6 ) was studied by using fluorescence spectroscopy. VB 6 can exist in one of three forms (the acidic form, neutral zwitterionic form and basic form) depending on pH. The fluorescence intensities of acidic and basic forms of VB 6 remarkably decreased in presence of SCX6. SCX6 preferred to form 1:1 inclusion complexes with acidic and basic forms of VB 6 but hardly form inclusion complex with neutral zwitterionic form. According to the nonlinear curve fitting method, the inclusion constant (K) for the formation of inclusion complexes of acidic and basic forms of VB 6 with SCX6 were evaluated to be 1.4 9 10 4 and 9 9 10 3 L/mol, respectively. The binding affinity of SCX6 towards acidic form is attributed to hydrogen bonds and hydrophobic interaction, furthermore, additional electrostatic interaction also plays a crucial role. The possible inclusion mode was given by 1 H NMR technique.

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Enantioselective hydrolysis of (R/S)-Naproxen methyl ester with sol–gel encapculated lipase in presence of calix[n]arene derivatives

Cited by 38 publications

References 47 publications

Nanomaterial‐Based Biocatalyst

Nanomaterial‐Based Biocatalyst

Enantioselective hydrolysis of (R,S)-Naproxen methyl ester using Candida rugosa lipase with calix[4]arene derivatives

Spectroscopic studies on the inclusion interaction of p-sulfonatocalix[6]arene with vitamin B6

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