Enantioselective intramolecular tandem cyclization of o-alkynylbenzamides: generation of enantioenriched CF₃-containing spiro-isoindolinone-indoles

Abstract

Enantioselective intramolecular tandem cyclization of dielectrophile-dinucleophile assembled o-alkynylbenzamides was realized using a chiral phosphoric acid as catalyst. A large variety of biologically important spiro-isoindolinone-indoles were achieved in moderate to good...