Enantioselective LC-MS/MS determination of antidepressants, β-blockers and metabolites in agricultural soil, compost and digested sewage sludge

Nanocrystalline Porous Materials for Chiral Separation: Synthesis, Mechanisms, and Applications

“…Such prominence renders it a veritable "popular" element within these spheres. 1,2 Following the notoriety of the thalidomide tragedy during the 1950s and 1960s, the prevalence of chiral drugs across diverse therapeutic classes and their substantial market shares compelled scientists to seek efficacious methods of gaining access to optically pure enantiomers. 3−5 Presently, there are three main ways to obtain it, including extraction of natural chiral drugs, 6 asymmetric synthesis, 7 and chiral separation.…”

“…Its significance reverberates across various domains, notably encompassing pharmaceuticals, agrochemicals, and other categories of fine chemicals. Such prominence renders it a veritable “popular” element within these spheres. , Following the notoriety of the thalidomide tragedy during the 1950s and 1960s, the prevalence of chiral drugs across diverse therapeutic classes and their substantial market shares compelled scientists to seek efficacious methods of gaining access to optically pure enantiomers. − Presently, there are three main ways to obtain it, including extraction of natural chiral drugs, asymmetric synthesis, and chiral separation . Notably, chiral separation garners favor owing to its capacity for quantitative yield, environmental compatibility, and heightened atom economy. , Chiral materials have demonstrated significant prowess in stability, separation efficiency, and mechanistic investigations, thereby furnishing the indispensable chiral milieu requisite for effective separations. − This observation finds ample support in the prior utilization of a diverse array of materials, ranging from cyclodextrins (CDs), crown ethers, proteins, DNA, and polysaccharide derivatives to macrocyclic antibiotics .…”