Enantioselective organocatalytic Friedel–Crafts reaction of electron-rich phenols and isatins by Takemoto’s thiourea catalyst

The 3-substituted-3-hydroxy-2-oxindole scaffolds are not only widely encountered in bioactive compounds but also serve as versatile building blocks for the construction of diverse valuable architectures. Although numerous synthetic methodologies have been developed over the past decades, the asymmetric addition of nucleophiles or their equivalents to isatin substrates has proved to be one of the most efficient strategies for the synthesis of chiral 3-substituted-3-hydroxy-2-oxindoles. This Short Review aims to summarize the significant progress achieved in this field in recent years, with particular attention paid to reaction development, mechanism, and stereo-induction models.

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Enantioselective organocatalytic Friedel–Crafts reaction of electron-rich phenols and isatins by Takemoto’s thiourea catalyst

Cited by 2 publications

References 30 publications

Asymmetric synthesis of spiro[4H-chromene-3,3′-oxindoles] via a squaramide-organocatalytic three-component cascade Knoevenagel/Michael/cyclization sequence

Asymmetric synthesis of spiro[4H-chromene-3,3′-oxindoles] via a squaramide-organocatalytic three-component cascade Knoevenagel/Michael/cyclization sequence

Recent Advances in Asymmetric Addition Reactions to Isatins

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