Enantioselective Organocatalyzed Domino Synthesis of Six-Membered Carbocycles

Abstract

Abstract:Polysubstituted chiral cyclohexanes and cyclohexenes are important building blocks in organic synthesis. From historical and pioneer reports to the most recent accounts, this review focuses on domino enantioselective organocatalytic methodologies that have allowed the control of the relative and absolute configurations of up to six stereogenic centers in the construction of these versatile molecular architectures.

Harnessing alcohols as sustainable reagents for late-stage functionalisation: synthesis of drugs and bio-inspired compounds

“…130,131 Cycloalkane and N-heterocycles are omnipresent in basic structural motifs in chiral or bioactive scaffolds and play a vital role in the chemical and pharmaceutical industries. [132][133][134][135] The quest for a three-dimensional biological space where cyclic organic compounds with diverse functional modifications can efficiently bind and connect is the main focus in drug development. 136 Developing cyclic moieties with a specific stereochemistry and suitable structure or size is a highly desirable challenge for researchers.…”

Polyenolate-mediated reaction cascade initiated by higher-order-cycloaddition for the construction of polycarbocyclic scaffolds

“…Cycloadditions constitute a highly reliable synthetic tool commonly employed for the preparation of both carbo- and heterocyclic systems with the Diels–Alder reaction and its hetero-versions being the most prominent examples. 7…”