2012
DOI: 10.1007/s10008-012-1859-4
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Enantioselective recognition of penicillamine enantiomers on bovine serum albumin-modified glassy carbon electrode

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Cited by 22 publications
(8 citation statements)
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“…In the presence of Phe, the peak current decreased more significantly for the l -enantiomer than that of the d -enantiomer, which is consistent with the change tendency of R ct ( R ct L = 264.3 Ω, R ct D = 209.5 Ω). This result reveals that the interaction between l -Phe and BSA is stronger than that of d -Phe . The difference of the cathodic peak current (Δ I = I L – I D ) between the l - and d -isomer was determined as −54.7 μA, indicating the effective chiral recognition ability of the as-prepared BSA-EG.…”
Section: Resultsmentioning
confidence: 83%
See 1 more Smart Citation
“…In the presence of Phe, the peak current decreased more significantly for the l -enantiomer than that of the d -enantiomer, which is consistent with the change tendency of R ct ( R ct L = 264.3 Ω, R ct D = 209.5 Ω). This result reveals that the interaction between l -Phe and BSA is stronger than that of d -Phe . The difference of the cathodic peak current (Δ I = I L – I D ) between the l - and d -isomer was determined as −54.7 μA, indicating the effective chiral recognition ability of the as-prepared BSA-EG.…”
Section: Resultsmentioning
confidence: 83%
“…This result reveals that the interaction between L-Phe and BSA is stronger than that of D-Phe. 34 The difference of the cathodic peak current (ΔI = I L − I D ) between the L-and D-isomer was determined as −54.7 μA, indicating the effective chiral recognition ability of the asprepared BSA-EG. DPV was employed to further estimate the The bare gold electrode lacks chiral recognition sites and cannot recognize amino acid enantiomers (Figure S3).…”
mentioning
confidence: 96%
“…Therefore, recognizing chiral enantiomers is of great significance for drug design and understanding the metabolism and regulation in organisms. At present, the identification and resolution of chiral molecules are usually achieved by means of high-performance liquid chromatography [ 3 ], capillary electrophoresis [ 4 ], electrochemistry [ 5 ], and circular dichroism [ 6 ], which are often time-consuming, require cost-ineffective equipment, produce low responses, and present difficulty achieving real-time online analysis. Consequently, the development of a new type of enantiomer recognition platform is key to meeting the needs of label-free, highly sensitive, fast-response detection.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, it is also the midbody of amino-acid-type anticancer drugs, such as styrene acrylic ammonia benzyl and formic acid soluble sarcoma. [31][32][33] Hence, the enantioselective recognition of Phe enantiomers using a BSA-modied chiral interface was investigated. 19 Some other discrimination techniques for Phe have been reported, such as chromatography, 20-22 capillary electrochromatography, 23,24 Fourier transform infrared spectroscopy 25 and electrochemical detection.…”
Section: Introductionmentioning
confidence: 99%
“…Bovine serum albumin (BSA) and human serum albumin have been used previously as chiral selectors. [31][32][33] Hence, the enantioselective recognition of Phe enantiomers using a BSA-modied chiral interface was investigated. First, gold nanoparticles (AuNPs) were electrodeposited on glassy carbon electrodes (GCEs), which provides a stable and rough surface to immobilize biomolecules favorably, 34 and then BSA was adsorbed on the gold-nanoparticle-modied electrodes.…”
Section: Introductionmentioning
confidence: 99%