1987
DOI: 10.1007/bf00251938
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Enantioselective reduction of acetyldimethylphenylsilane by Trigonopsis variabilis (DSM 70714)

Abstract: Summary. Growing and resting cells of the yeastTrigonapsis variabilis (DSM 70714) can be used for the enantioselective reduction of the organosilicon compound acetyldimethylphenylsilane (J) to give optically active (R)-(1-hydroxyethyl)dimethylphenylsilane [(R)-2] in good yields. The enantiomeric purity of the isolated product was determined tobe 62-86% ee depending on the substrate concentration used. Both substrate and product caused an inhibition of the reaction at concentrations higher than 0.35 and 0.5 … Show more

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Cited by 44 publications
(31 citation statements)
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“…The results decribed in this paper and elsewhere [1][2][3][4][5][6][7][8][9]12] demonstrate that enantioselective biotransformations may be useful for the synthesis of optically active organosilicon compounds on a preparative scale.…”
Section: Introductionsupporting
confidence: 52%
See 2 more Smart Citations
“…The results decribed in this paper and elsewhere [1][2][3][4][5][6][7][8][9]12] demonstrate that enantioselective biotransformations may be useful for the synthesis of optically active organosilicon compounds on a preparative scale.…”
Section: Introductionsupporting
confidence: 52%
“…1-3), various strains of microorganisms (bacteria, yeasts, fungi, algae) were found to reduce the carbonyl groups of cyclic and acyclic acylsilanes stereoselectively to give the corresponding (1-hydroxyalkyl)silanes [1][2][3][4][5][6][7][8]. The enantioselective reduction of 1,1-dimethyl-l-si1a-cyclohexan-2-one (1) with cells of the yeast Kloeckera corticis (ATCC 20109) is an example of this type of biotransformation (Scheme 1; for a preliminary report on this reaction, see ref.…”
Section: Introductionmentioning
confidence: 99%
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“…[9,13,15,16] These transformations were accomplished both with whole microorganisms and free enzymes. This work has been reviewed in greater detail previously, [17] and the reader is referred to this paper forf urther details about these biocatalytic reactions.…”
Section: Inspired By Naturementioning
confidence: 99%
“…During our investigations on the synthesis of optically active organosilicon compounds by use of stereoselective biotransformations, both whole microbial cells [1][2][3][4][5][6] and free enzymes [7] were used as biocatalysts (for recent reviews see refs. [8][9][10].…”
Section: Introductionmentioning
confidence: 99%