Enantioselective synthesis of unsymmetrical α,α-diarylacetates via organocatalyzed formal C–H insertion reactions of sulfoxonium ylides with indoles and pyrroles

Abstract

A chiral phosphoric acid-catalyzed highly enantioselective formal C–H insertion reaction of N–H free indole and pyrrole with sulfoxonium ylides has been developed (up to 95% yield and 97% ee).