Enantioselective synthesis of α-chiral sulfonates through palladium-catalyzed Tsuji–Trost sulfonylation with sulfur dioxide

Abstract

α-Chiral sulfonates have remained largely uncharted territory, primarily due to the intrinsic difficulties associated with achieving stereocontrol. In this study, we present an innovative three-component palladium-catalyzed asymmetric Tsuji-Trost sulfonylation protocol,...