Enantioselective Total Synthesis of (R,R)-Blumenol B and d9-(R,R)-Blumenol B

Abstract

C13-norisoprenoids are of particular importance to grapes and wines, as these molecules influence wine aroma and have been shown to significantly contribute to the distinct character of various wine varieties. Blumenol B is a putative precursor to a number of important wine aroma compounds, including the well-known compounds theaspirone and vitispirane. The enantioselective synthesis of (R,R)-blumenol B from commercially available 4-oxoisophorone was achieved using a short and easily scaleable route, which was then successfully applied to the synthesis of poly-deuterated d9-blumenol B.

Synthesis and Characterization of some Pyrazoline derivatives from Chalcones containing azo and ether groups

“…1,4-Michael addition [9] to chalcone interfers rations with 1,2 Claise-addition [10], depending on the nucleophile force, chalcone structural as well as temperature. Through the above addition reactions many important heterocyclic compounds which have the biological effectiveness such as pyrimidines [11], thiazines [12], oxazines [13], isoxazoles [14] and pyrazolines have been prepared. [15].…”