Enantioselective α‐Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β′‐Diketones

Abstract

We herein describe the first enantioselective acarbonylative arylation, providing a diverse set of chiral spiro b,b'-diketones bearing various ring sizes and functionalities in high yields and good to excellent enantioselectivities. Calculations suggest the transformation proceeds through reductive elimination instead of nucleophilic addition pathway. Scheme 1. Design of enantioselective a-carbonylative arylation. Scheme 2. Asymmetric carbonylation of arenes.